A versatile synthesis of tetraester polyamine lipids for gene transfection

Mike E. Lizarzaburu, Mark J. Kurth, Michael H. Nantz

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The preparation of polyamine lipids via Michael addition of diamines to tetraester bisacrylates is described. A new pentaerythritol protection strategy enabled the synthesis of a bis(p-methoxybenzyl)diether diol which was used to prepare the saturated and unsaturated diester cores.

Original languageEnglish (US)
Pages (from-to)8985-8988
Number of pages4
JournalTetrahedron Letters
Volume40
Issue number51
StatePublished - Dec 17 1999

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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