A versatile synthesis of tetraester polyamine lipids for gene transfection

Mike E. Lizarzaburu, Mark J. Kurth, Michael H. Nantz

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The preparation of polyamine lipids via Michael addition of diamines to tetraester bisacrylates is described. A new pentaerythritol protection strategy enabled the synthesis of a bis(p-methoxybenzyl)diether diol which was used to prepare the saturated and unsaturated diester cores.

Original languageEnglish (US)
Pages (from-to)8985-8988
Number of pages4
JournalTetrahedron Letters
Volume40
Issue number51
StatePublished - Dec 17 1999

Fingerprint

Diamines
Polyamines
Transfection
Genes
Lipids
pentaerythritol

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Lizarzaburu, M. E., Kurth, M. J., & Nantz, M. H. (1999). A versatile synthesis of tetraester polyamine lipids for gene transfection. Tetrahedron Letters, 40(51), 8985-8988.

A versatile synthesis of tetraester polyamine lipids for gene transfection. / Lizarzaburu, Mike E.; Kurth, Mark J.; Nantz, Michael H.

In: Tetrahedron Letters, Vol. 40, No. 51, 17.12.1999, p. 8985-8988.

Research output: Contribution to journalArticle

Lizarzaburu, ME, Kurth, MJ & Nantz, MH 1999, 'A versatile synthesis of tetraester polyamine lipids for gene transfection', Tetrahedron Letters, vol. 40, no. 51, pp. 8985-8988.
Lizarzaburu ME, Kurth MJ, Nantz MH. A versatile synthesis of tetraester polyamine lipids for gene transfection. Tetrahedron Letters. 1999 Dec 17;40(51):8985-8988.
Lizarzaburu, Mike E. ; Kurth, Mark J. ; Nantz, Michael H. / A versatile synthesis of tetraester polyamine lipids for gene transfection. In: Tetrahedron Letters. 1999 ; Vol. 40, No. 51. pp. 8985-8988.
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