A versatile synthesis of tetraester polyamine lipids for gene transfection

Mike E. Lizarzaburu; Mark J. Kurth; Michael H. Nantz

A versatile synthesis of tetraester polyamine lipids for gene transfection

Mike E. Lizarzaburu, Mark J. Kurth, Michael H. Nantz

Chemistry

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The preparation of polyamine lipids via Michael addition of diamines to tetraester bisacrylates is described. A new pentaerythritol protection strategy enabled the synthesis of a bis(p-methoxybenzyl)diether diol which was used to prepare the saturated and unsaturated diester cores.

Original language	English (US)
Pages (from-to)	8985-8988
Number of pages	4
Journal	Tetrahedron Letters
Volume	40
Issue number	51
State	Published - Dec 17 1999

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Drug Discovery

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title = "A versatile synthesis of tetraester polyamine lipids for gene transfection",

abstract = "The preparation of polyamine lipids via Michael addition of diamines to tetraester bisacrylates is described. A new pentaerythritol protection strategy enabled the synthesis of a bis(p-methoxybenzyl)diether diol which was used to prepare the saturated and unsaturated diester cores.",

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year = "1999",

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language = "English (US)",

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T1 - A versatile synthesis of tetraester polyamine lipids for gene transfection

AU - Lizarzaburu, Mike E.

AU - Kurth, Mark J.

AU - Nantz, Michael H.

PY - 1999/12/17

Y1 - 1999/12/17

N2 - The preparation of polyamine lipids via Michael addition of diamines to tetraester bisacrylates is described. A new pentaerythritol protection strategy enabled the synthesis of a bis(p-methoxybenzyl)diether diol which was used to prepare the saturated and unsaturated diester cores.

AB - The preparation of polyamine lipids via Michael addition of diamines to tetraester bisacrylates is described. A new pentaerythritol protection strategy enabled the synthesis of a bis(p-methoxybenzyl)diether diol which was used to prepare the saturated and unsaturated diester cores.

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M3 - Article

AN - SCOPUS:0033579645

VL - 40

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 51

ER -

A versatile synthesis of tetraester polyamine lipids for gene transfection

Abstract

ASJC Scopus subject areas

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