A vegetable-fruit-soy dietary pattern protects against breast cancer among postmenopausal Singapore Chinese women

Lesley M. Butler, Anna H. Wu, Renwei Wang, Woon Puay Koh, Jian Min Yuan, Mimi C. Yu

Research output: Contribution to journalArticle

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Abstract

Background: Prospective epidemiologic studies in Asian populations consistently show that soy is protective against breast cancer. Objective: The objective was to prospectively evaluate whether the protective effect of soy is due to soy isoflavones alone or to their combination with other beneficial dietary factors in an Asian population. Design: Using principal components analysis, we previously identified a "meat-dim sum" pattern characterized by meat, starch, and dim sum items and a "vegetable-fruit- soy" pattern characterized by cruciferous vegetables, fruit, and tofu items in a population-based cohort of Singapore Chinese initiated between 1993 and 1998. Component scores representing intakes of each pattern were used in multivariable Cox regression models to analyze the relation between diet at baseline and breast cancer incidence. Results: As of 31 December 2005, 629 incident breast cancer cases had been diagnosed among the 34,028 women. With greater intake of the vegetable-fruit-soy dietary pattern, we observed a dose-dependent trend (P < 0.01) for decreasing breast cancer risk among postmenopausal women [hazard ratio (HR): 0.70; 95% CI: 0.51, 0.95 for the fourth compared with first quartile]. A stronger association for the vegetable-fruit-soy pattern was observed among postmenopausal women with ≥5 y of follow-up (HR: 0.57; 95% CI: 0.36, 0.88; P for trend <0.01). No trend was observed for a greater intake of the meat-dim sum dietary pattern and increased breast cancer risk. Conclusion: Our findings support the hypothesis that a diet characterized by vegetables, fruit, and soy has an early-acting protective effect on breast carcinogenesis.

Original languageEnglish (US)
Pages (from-to)1013-1019
Number of pages7
JournalAmerican Journal of Clinical Nutrition
Volume91
Issue number4
DOIs
StatePublished - Apr 1 2010
Externally publishedYes

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Singapore
Vegetables
Fruit
Breast Neoplasms
Meat
Population
Diet
Soy Foods
Isoflavones
Principal Component Analysis
Proportional Hazards Models
Starch
Epidemiologic Studies
Carcinogenesis
Breast
Prospective Studies
Incidence

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Medicine(all)

Cite this

A vegetable-fruit-soy dietary pattern protects against breast cancer among postmenopausal Singapore Chinese women. / Butler, Lesley M.; Wu, Anna H.; Wang, Renwei; Koh, Woon Puay; Yuan, Jian Min; Yu, Mimi C.

In: American Journal of Clinical Nutrition, Vol. 91, No. 4, 01.04.2010, p. 1013-1019.

Research output: Contribution to journalArticle

Butler, Lesley M. ; Wu, Anna H. ; Wang, Renwei ; Koh, Woon Puay ; Yuan, Jian Min ; Yu, Mimi C. / A vegetable-fruit-soy dietary pattern protects against breast cancer among postmenopausal Singapore Chinese women. In: American Journal of Clinical Nutrition. 2010 ; Vol. 91, No. 4. pp. 1013-1019.
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