Abstract
Background: Prospective epidemiologic studies in Asian populations consistently show that soy is protective against breast cancer. Objective: The objective was to prospectively evaluate whether the protective effect of soy is due to soy isoflavones alone or to their combination with other beneficial dietary factors in an Asian population. Design: Using principal components analysis, we previously identified a "meat-dim sum" pattern characterized by meat, starch, and dim sum items and a "vegetable-fruit- soy" pattern characterized by cruciferous vegetables, fruit, and tofu items in a population-based cohort of Singapore Chinese initiated between 1993 and 1998. Component scores representing intakes of each pattern were used in multivariable Cox regression models to analyze the relation between diet at baseline and breast cancer incidence. Results: As of 31 December 2005, 629 incident breast cancer cases had been diagnosed among the 34,028 women. With greater intake of the vegetable-fruit-soy dietary pattern, we observed a dose-dependent trend (P < 0.01) for decreasing breast cancer risk among postmenopausal women [hazard ratio (HR): 0.70; 95% CI: 0.51, 0.95 for the fourth compared with first quartile]. A stronger association for the vegetable-fruit-soy pattern was observed among postmenopausal women with ≥5 y of follow-up (HR: 0.57; 95% CI: 0.36, 0.88; P for trend <0.01). No trend was observed for a greater intake of the meat-dim sum dietary pattern and increased breast cancer risk. Conclusion: Our findings support the hypothesis that a diet characterized by vegetables, fruit, and soy has an early-acting protective effect on breast carcinogenesis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1013-1019 |
| Number of pages | 7 |
| Journal | American Journal of Clinical Nutrition |
| Volume | 91 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1 2010 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics
- Medicine(all)
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A vegetable-fruit-soy dietary pattern protects against breast cancer among postmenopausal Singapore Chinese women. / Butler, Lesley M.; Wu, Anna H.; Wang, Renwei; Koh, Woon Puay; Yuan, Jian Min; Yu, Mimi C.
In: American Journal of Clinical Nutrition, Vol. 91, No. 4, 01.04.2010, p. 1013-1019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A vegetable-fruit-soy dietary pattern protects against breast cancer among postmenopausal Singapore Chinese women
AU - Butler, Lesley M.
AU - Wu, Anna H.
AU - Wang, Renwei
AU - Koh, Woon Puay
AU - Yuan, Jian Min
AU - Yu, Mimi C.
PY - 2010/4/1
Y1 - 2010/4/1
N2 - Background: Prospective epidemiologic studies in Asian populations consistently show that soy is protective against breast cancer. Objective: The objective was to prospectively evaluate whether the protective effect of soy is due to soy isoflavones alone or to their combination with other beneficial dietary factors in an Asian population. Design: Using principal components analysis, we previously identified a "meat-dim sum" pattern characterized by meat, starch, and dim sum items and a "vegetable-fruit- soy" pattern characterized by cruciferous vegetables, fruit, and tofu items in a population-based cohort of Singapore Chinese initiated between 1993 and 1998. Component scores representing intakes of each pattern were used in multivariable Cox regression models to analyze the relation between diet at baseline and breast cancer incidence. Results: As of 31 December 2005, 629 incident breast cancer cases had been diagnosed among the 34,028 women. With greater intake of the vegetable-fruit-soy dietary pattern, we observed a dose-dependent trend (P < 0.01) for decreasing breast cancer risk among postmenopausal women [hazard ratio (HR): 0.70; 95% CI: 0.51, 0.95 for the fourth compared with first quartile]. A stronger association for the vegetable-fruit-soy pattern was observed among postmenopausal women with ≥5 y of follow-up (HR: 0.57; 95% CI: 0.36, 0.88; P for trend <0.01). No trend was observed for a greater intake of the meat-dim sum dietary pattern and increased breast cancer risk. Conclusion: Our findings support the hypothesis that a diet characterized by vegetables, fruit, and soy has an early-acting protective effect on breast carcinogenesis.
AB - Background: Prospective epidemiologic studies in Asian populations consistently show that soy is protective against breast cancer. Objective: The objective was to prospectively evaluate whether the protective effect of soy is due to soy isoflavones alone or to their combination with other beneficial dietary factors in an Asian population. Design: Using principal components analysis, we previously identified a "meat-dim sum" pattern characterized by meat, starch, and dim sum items and a "vegetable-fruit- soy" pattern characterized by cruciferous vegetables, fruit, and tofu items in a population-based cohort of Singapore Chinese initiated between 1993 and 1998. Component scores representing intakes of each pattern were used in multivariable Cox regression models to analyze the relation between diet at baseline and breast cancer incidence. Results: As of 31 December 2005, 629 incident breast cancer cases had been diagnosed among the 34,028 women. With greater intake of the vegetable-fruit-soy dietary pattern, we observed a dose-dependent trend (P < 0.01) for decreasing breast cancer risk among postmenopausal women [hazard ratio (HR): 0.70; 95% CI: 0.51, 0.95 for the fourth compared with first quartile]. A stronger association for the vegetable-fruit-soy pattern was observed among postmenopausal women with ≥5 y of follow-up (HR: 0.57; 95% CI: 0.36, 0.88; P for trend <0.01). No trend was observed for a greater intake of the meat-dim sum dietary pattern and increased breast cancer risk. Conclusion: Our findings support the hypothesis that a diet characterized by vegetables, fruit, and soy has an early-acting protective effect on breast carcinogenesis.
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UR - http://www.scopus.com/inward/citedby.url?scp=77950464161&partnerID=8YFLogxK
U2 - 10.3945/ajcn.2009.28572
DO - 10.3945/ajcn.2009.28572
M3 - Article
C2 - 20181808
AN - SCOPUS:77950464161
VL - 91
SP - 1013
EP - 1019
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
SN - 0002-9165
IS - 4
ER -