A Triterpene Glycoside from Black Cohosh that Inhibits Osteoclastogenesis by Modulating RANKL and TNFα Signaling Pathways

Samuel X. Qiu, Chun Dan, Li Sheng Ding, Shulin Peng, Shao Nong Chen, Norman R. Farnsworth, Jan Nolta, Michael L. Gross, Ping Zhou

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

Osteoporosis is a major age-related source of morbidity and mortality. Increased bone resorption mediated by osteoclasts is central to its pathogenesis. Cytokines, particularly RANKL and TNFα, are often increased under pathologic conditions, leading to enhanced osteoclastogenesis. Black cohosh (Actaea/Cimicifuga racemosa L), a popular herbal supplement for the treatment of menopausal symptoms, was recently shown to have the beneficial effect of preventing bone loss. Here, we demonstrate that 25-acetylcimigenol xylopyranoside (ACCX), a triterpenoid glycoside isolated from black cohosh, potently blocks in vitro osteoclastogenesis induced by either RANKL or TNFα. This blockage of osteoclastogenesis elicited by ACCX results from abrogation of the NF-κB and ERK pathways induced by either RANKL or TNFα, respectively. Importantly, this compound attenuates TNFα-induced bone loss in vivo. Therefore, ACCX represents a potential lead for the development of a new class of antiosteoporosis agents.

Original languageEnglish (US)
Pages (from-to)860-869
Number of pages10
JournalChemistry and Biology
Volume14
Issue number7
DOIs
StatePublished - Jul 30 2007
Externally publishedYes

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Keywords

  • CHEMBIOL
  • SIGNALING

ASJC Scopus subject areas

  • Organic Chemistry

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