A tripartite cocktail of chimeric monoclonal antibodies passively protects mice against ricin, staphylococcal enterotoxin B and Clostridium perfringens epsilon toxin

Erin K. Sully, Kevin Whaley, Natasha Bohorova, Ognian Bohorov, Charles Goodman, Do Kim, Michael Pauly, Jesus Velasco, Frederick W. Holtsberg, Eric Stavale, M. Javad Aman, Chandra Tangudu, Francisco A Uzal, Nicholas J. Mantis, Larry Zeitlin

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Due to the fast-acting nature of ricin, staphylococcal enterotoxin B (SEB), and Clostridium perfringens epsilon toxin (ETX), it is necessary that therapeutic interventions following a bioterrorism incident by one of these toxins occur as soon as possible after intoxication. Moreover, because the clinical manifestations of intoxication by these agents are likely to be indistinguishable from each other, especially following aerosol exposure, we have developed a cocktail of chimeric monoclonal antibodies that is capable of neutralizing all three toxins. The efficacy of this cocktail was demonstrated in mouse models of lethal dose toxin challenge.

Original languageEnglish (US)
Pages (from-to)36-41
Number of pages6
JournalToxicon
Volume92
DOIs
StatePublished - Dec 15 2014

Keywords

  • Antibody
  • Biodefense
  • Therapeutic
  • Toxin

ASJC Scopus subject areas

  • Toxicology

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    Sully, E. K., Whaley, K., Bohorova, N., Bohorov, O., Goodman, C., Kim, D., Pauly, M., Velasco, J., Holtsberg, F. W., Stavale, E., Aman, M. J., Tangudu, C., Uzal, F. A., Mantis, N. J., & Zeitlin, L. (2014). A tripartite cocktail of chimeric monoclonal antibodies passively protects mice against ricin, staphylococcal enterotoxin B and Clostridium perfringens epsilon toxin. Toxicon, 92, 36-41. https://doi.org/10.1016/j.toxicon.2014.09.006