Abstract
We have applied cDNA hybridization selection to nine YACs spanning 3 Mb of genomic DNA from a region centromeric to HLA-A to the histone cluster that lies telomeric to the human major histocompatibility complex (MHC). In addition to Class I genes and pseudogenes, we describe over 63 genes and 23 additional expressed sequence tags distributed throughout the region. Many of the full-length genes belong to gene families. Prominent among these are a group of genes encoding proteins showing homology to the carboxylterminal sequences of butyrophilin and an additional group of zinc finger genes. We also detected several previously undefined genes that are specifically expressed in cells of the immune system, indicating a more complex role of the MHC in the immune response than has been appreciated.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 70-85 |
| Number of pages | 16 |
| Journal | Genomics |
| Volume | 36 |
| Issue number | 1 |
| DOIs | |
| State | Published - Aug 15 1996 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Genetics
Cite this
A transcription map of the major histocompatibility complex (MHC) class I region. / Gruen, J. R.; Nalabolu, S. R.; Chu, T. W.; Bowlus, Christopher; Fan, W. F.; Goei, V. L.; Wei, H.; Sivakamasundari, R.; Liu, Y. C.; Xu, H. X.; Parimoo, S.; Nallur, G.; Ajioka, R.; Shukla, H.; Bray-Ward, P.; Pan, J.; Weissman, S. M.
In: Genomics, Vol. 36, No. 1, 15.08.1996, p. 70-85.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A transcription map of the major histocompatibility complex (MHC) class I region
AU - Gruen, J. R.
AU - Nalabolu, S. R.
AU - Chu, T. W.
AU - Bowlus, Christopher
AU - Fan, W. F.
AU - Goei, V. L.
AU - Wei, H.
AU - Sivakamasundari, R.
AU - Liu, Y. C.
AU - Xu, H. X.
AU - Parimoo, S.
AU - Nallur, G.
AU - Ajioka, R.
AU - Shukla, H.
AU - Bray-Ward, P.
AU - Pan, J.
AU - Weissman, S. M.
PY - 1996/8/15
Y1 - 1996/8/15
N2 - We have applied cDNA hybridization selection to nine YACs spanning 3 Mb of genomic DNA from a region centromeric to HLA-A to the histone cluster that lies telomeric to the human major histocompatibility complex (MHC). In addition to Class I genes and pseudogenes, we describe over 63 genes and 23 additional expressed sequence tags distributed throughout the region. Many of the full-length genes belong to gene families. Prominent among these are a group of genes encoding proteins showing homology to the carboxylterminal sequences of butyrophilin and an additional group of zinc finger genes. We also detected several previously undefined genes that are specifically expressed in cells of the immune system, indicating a more complex role of the MHC in the immune response than has been appreciated.
AB - We have applied cDNA hybridization selection to nine YACs spanning 3 Mb of genomic DNA from a region centromeric to HLA-A to the histone cluster that lies telomeric to the human major histocompatibility complex (MHC). In addition to Class I genes and pseudogenes, we describe over 63 genes and 23 additional expressed sequence tags distributed throughout the region. Many of the full-length genes belong to gene families. Prominent among these are a group of genes encoding proteins showing homology to the carboxylterminal sequences of butyrophilin and an additional group of zinc finger genes. We also detected several previously undefined genes that are specifically expressed in cells of the immune system, indicating a more complex role of the MHC in the immune response than has been appreciated.
UR - http://www.scopus.com/inward/record.url?scp=0030586949&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030586949&partnerID=8YFLogxK
U2 - 10.1006/geno.1996.0427
DO - 10.1006/geno.1996.0427
M3 - Article
C2 - 8812418
AN - SCOPUS:0030586949
VL - 36
SP - 70
EP - 85
JO - Genomics
JF - Genomics
SN - 0888-7543
IS - 1
ER -