A topography of executive functions and their interactions revealed by functional magnetic resonance imaging

Catherine Fassbender, K. Murphy, J. J. Foxe, G. R. Wylie, D. C. Javitt, I. H. Robertson, H. Garavan

Research output: Contribution to journalArticle

199 Citations (Scopus)

Abstract

We used fMRI to study the brain processes involved in the executive control of behavior. The Sustained Attention to Response Task (SART), which allows unpredictable and predictable NOGO events to be contrasted, was imaged using a mixed (block and event-related) fMRI design to examine tonic and phasic processes involved in response inhibition, error detection, conflict monitoring and sustained attention. A network of regions, including right ventral prefrontal cortex (PFC), left dorsolateral PFC (DLPFC) and right inferior parietal cortex, was activated for successful unpredictable inhibitions, while rostral anterior cingulate was implicated in error processing and the pre-SMA in conflict monitoring. Furthermore, the pattern of correlations between left dorsolateral PFC, implicated in task-set maintenance, and the pre-SMA were indicative of a tight coupling between prefrontally mediated control and conflict levels monitored more posteriorly. The results reveal that the executive control of behavior can be separated into distinct functions performed by discrete cortical regions.

Original languageEnglish (US)
Pages (from-to)132-143
Number of pages12
JournalCognitive Brain Research
Volume20
Issue number2
DOIs
StatePublished - Jul 1 2004
Externally publishedYes

Fingerprint

Executive Function
Prefrontal Cortex
Magnetic Resonance Imaging
Parietal Lobe
Gyrus Cinguli
Maintenance
Brain
Conflict (Psychology)
Inhibition (Psychology)

Keywords

  • Anterior cingulate cortex
  • Attentional control
  • Cognition
  • Dorsolateral prefrontal cortex
  • Functional MRI
  • Neural basis of behavior

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Cite this

A topography of executive functions and their interactions revealed by functional magnetic resonance imaging. / Fassbender, Catherine; Murphy, K.; Foxe, J. J.; Wylie, G. R.; Javitt, D. C.; Robertson, I. H.; Garavan, H.

In: Cognitive Brain Research, Vol. 20, No. 2, 01.07.2004, p. 132-143.

Research output: Contribution to journalArticle

Fassbender, Catherine ; Murphy, K. ; Foxe, J. J. ; Wylie, G. R. ; Javitt, D. C. ; Robertson, I. H. ; Garavan, H. / A topography of executive functions and their interactions revealed by functional magnetic resonance imaging. In: Cognitive Brain Research. 2004 ; Vol. 20, No. 2. pp. 132-143.
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