A tissue-engineered jellyfish with biomimetic propulsion

Janna C. Nawroth, Hyungsuk Lee, Adam W. Feinberg, Crystal M Ripplinger, Megan L. McCain, Anna Grosberg, John O. Dabiri, Kevin Kit Parker

Research output: Contribution to journalArticle

299 Citations (Scopus)

Abstract

Reverse engineering of biological form and function requires hierarchical design over several orders of space and time. Recent advances in the mechanistic understanding of biosynthetic compound materials, computer-aided design approaches in molecular synthetic biology and traditional soft robotics, and increasing aptitude in generating structural and chemical microenvironments that promote cellular self-organization have enhanced the ability to recapitulate such hierarchical architecture in engineered biological systems. Here we combined these capabilities in a systematic design strategy to reverse engineer a muscular pump. We report the construction of a freely swimming jellyfish from chemically dissociated rat tissue and silicone polymer as a proof of concept. The constructs, termed 'medusoids', were designed with computer simulations and experiments to match key determinants of jellyfish propulsion and feeding performance by quantitatively mimicking structural design, stroke kinematics and animal-fluid interactions. The combination of the engineering design algorithm with quantitative benchmarks of physiological performance suggests that our strategy is broadly applicable to reverse engineering of muscular organs or simple life forms that pump to survive.

Original languageEnglish (US)
Pages (from-to)792-797
Number of pages6
JournalNature Biotechnology
Volume30
Issue number8
DOIs
StatePublished - Aug 2012
Externally publishedYes

Fingerprint

Biomimetics
Propulsion
Reverse engineering
Synthetic Biology
Tissue
Cellular Microenvironment
Computer-Aided Design
Benchmarking
Bioengineering
Robotics
Silicones
Biomechanical Phenomena
Pumps
Computer Simulation
Molecular Biology
Polymers
Stroke
Biological systems
Structural design
Rats

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Biotechnology
  • Molecular Medicine
  • Bioengineering
  • Biomedical Engineering

Cite this

Nawroth, J. C., Lee, H., Feinberg, A. W., Ripplinger, C. M., McCain, M. L., Grosberg, A., ... Parker, K. K. (2012). A tissue-engineered jellyfish with biomimetic propulsion. Nature Biotechnology, 30(8), 792-797. https://doi.org/10.1038/nbt.2269

A tissue-engineered jellyfish with biomimetic propulsion. / Nawroth, Janna C.; Lee, Hyungsuk; Feinberg, Adam W.; Ripplinger, Crystal M; McCain, Megan L.; Grosberg, Anna; Dabiri, John O.; Parker, Kevin Kit.

In: Nature Biotechnology, Vol. 30, No. 8, 08.2012, p. 792-797.

Research output: Contribution to journalArticle

Nawroth, JC, Lee, H, Feinberg, AW, Ripplinger, CM, McCain, ML, Grosberg, A, Dabiri, JO & Parker, KK 2012, 'A tissue-engineered jellyfish with biomimetic propulsion', Nature Biotechnology, vol. 30, no. 8, pp. 792-797. https://doi.org/10.1038/nbt.2269
Nawroth JC, Lee H, Feinberg AW, Ripplinger CM, McCain ML, Grosberg A et al. A tissue-engineered jellyfish with biomimetic propulsion. Nature Biotechnology. 2012 Aug;30(8):792-797. https://doi.org/10.1038/nbt.2269
Nawroth, Janna C. ; Lee, Hyungsuk ; Feinberg, Adam W. ; Ripplinger, Crystal M ; McCain, Megan L. ; Grosberg, Anna ; Dabiri, John O. ; Parker, Kevin Kit. / A tissue-engineered jellyfish with biomimetic propulsion. In: Nature Biotechnology. 2012 ; Vol. 30, No. 8. pp. 792-797.
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