A Theoretical study of the contrast recovery and variance of MAP reconstructions from PET data

Jinyi Qi, Richard M. Leahy

Research output: Contribution to journalArticle

141 Scopus citations

Abstract

We examine the spatial resolution and variance properties of PET images reconstructed using maximum a posteriori (MAP) or penalized-likelihood methods. Resolution is characterized by the contrast recovery coefficient (CRC) of the local impulse response. Simplified approximate expressions are derived for the local impulse response CRC's and variances for each voxel. Using these results we propose a practical scheme for selecting spatially variant smoothing parameters to optimize lesion detectability through maximization of the local CRC-tonoise ratio in the reconstructed image.

Original languageEnglish (US)
Pages (from-to)293-305
Number of pages13
JournalIEEE Transactions on Medical Imaging
Volume18
Issue number4
StatePublished - 1999
Externally publishedYes

Keywords

  • Hyperparameter estimation
  • Image resolution
  • Map estimation
  • Variance analysis

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Electrical and Electronic Engineering
  • Computer Science Applications
  • Computational Theory and Mathematics

Fingerprint Dive into the research topics of 'A Theoretical study of the contrast recovery and variance of MAP reconstructions from PET data'. Together they form a unique fingerprint.

  • Cite this