A technique for single-channel MR brain tissue segmentation

Application to a pediatric sample

Jagath C. Rajapakse, Jay N. Giedd, Charles DeCarli, John W. Snell, Alan McLaughlin, Yolanda C. Vauss, Amy L. Krain, Susan Hamburger, Judith L. Rapoport

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

A segmentation method is presented for gray matter, white matter, and cerebrospinal fluid (CSF) in thin-sliced single-channel brain magnetic resonance (MR) scans. The method is based on probabilistic modeling of intensity distributions and on a region growing technique. Interrater and intrarater reliabilities for the method were high, and comparison with phantom studies and hand-traced results from an experienced rarer indicated good validity. The method was designed to account for spatially dependent image intensity inhomogeneities. Segmentation of MR brain scans of 105 (56 male and 49 female) healthy children and adolescents showed that although the total brain volume was stable over age 4-18, white matter increased and gray matter decreased significantly. There were no sex differences in total gray and white matter growth after correction for total brain volume. White matter volume increased the most in superior and posterior regions and laterality effects were seen in hemisphere tissue volumes. These findings are consistent with other reports, and further validate the segmentation technique.

Original languageEnglish (US)
Pages (from-to)1053-1065
Number of pages13
JournalMagnetic Resonance Imaging
Volume14
Issue number9
DOIs
StatePublished - 1996
Externally publishedYes

Fingerprint

Pediatrics
Magnetic resonance
brain
magnetic resonance
Brain
Magnetic Resonance Spectroscopy
Tissue
Cerebrospinal fluid
lateral stability
Sex Characteristics
cerebrospinal fluid
Cerebrospinal Fluid
Hand
hemispheres
White Matter
inhomogeneity
Growth
Gray Matter

Keywords

  • Brain imaging
  • Cerebrospinal fluid
  • Gray matter
  • Magnetic resonance imaging
  • Region growing
  • White matter

ASJC Scopus subject areas

  • Biophysics
  • Clinical Biochemistry
  • Structural Biology
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

Cite this

Rajapakse, J. C., Giedd, J. N., DeCarli, C., Snell, J. W., McLaughlin, A., Vauss, Y. C., ... Rapoport, J. L. (1996). A technique for single-channel MR brain tissue segmentation: Application to a pediatric sample. Magnetic Resonance Imaging, 14(9), 1053-1065. https://doi.org/10.1016/S0730-725X(96)00113-0

A technique for single-channel MR brain tissue segmentation : Application to a pediatric sample. / Rajapakse, Jagath C.; Giedd, Jay N.; DeCarli, Charles; Snell, John W.; McLaughlin, Alan; Vauss, Yolanda C.; Krain, Amy L.; Hamburger, Susan; Rapoport, Judith L.

In: Magnetic Resonance Imaging, Vol. 14, No. 9, 1996, p. 1053-1065.

Research output: Contribution to journalArticle

Rajapakse, JC, Giedd, JN, DeCarli, C, Snell, JW, McLaughlin, A, Vauss, YC, Krain, AL, Hamburger, S & Rapoport, JL 1996, 'A technique for single-channel MR brain tissue segmentation: Application to a pediatric sample', Magnetic Resonance Imaging, vol. 14, no. 9, pp. 1053-1065. https://doi.org/10.1016/S0730-725X(96)00113-0
Rajapakse, Jagath C. ; Giedd, Jay N. ; DeCarli, Charles ; Snell, John W. ; McLaughlin, Alan ; Vauss, Yolanda C. ; Krain, Amy L. ; Hamburger, Susan ; Rapoport, Judith L. / A technique for single-channel MR brain tissue segmentation : Application to a pediatric sample. In: Magnetic Resonance Imaging. 1996 ; Vol. 14, No. 9. pp. 1053-1065.
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