A tale of two plaques: Convergent mechanisms of T-cell-mediated inflammation in psoriasis and atherosclerosis

April W. Armstrong, Stephanie V. Voyles, Ehrin J. Armstrong, Erin N. Fuller, John C Rutledge

Research output: Contribution to journalArticle

85 Scopus citations

Abstract

Psoriasis and atherosclerosis are diseases in which effector T lymphocytes such as Helper T cells type 1 (Th1) and 17 (Th17) play integral roles in disease pathogenesis and progression. Regulatory T cells (Treg) also exert clinically important anti-inflammatory effects that are pathologically altered in psoriasis and atherosclerosis. We review the immunological pathways involving Th1, Th17 and Treg cells that are common to psoriasis and atherosclerosis. These shared pathways provide the basis for mechanisms that may explain the epidemiologic observation that patients with psoriasis have an increased risk of heart disease. Improved understanding of these pathways will guide future experiments and may lead to the development of therapeutics that prevent or treat cardiovascular complications in patients with psoriasis.

Original languageEnglish (US)
Pages (from-to)544-549
Number of pages6
JournalExperimental Dermatology
Volume20
Issue number7
DOIs
StatePublished - Jul 2011

Keywords

  • Atherosclerosis
  • Psoriasis
  • Regulatory T cells
  • T-helper 1 cells
  • T-helper 17 cells

ASJC Scopus subject areas

  • Dermatology
  • Molecular Biology
  • Biochemistry

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