A systematic review of regional hyperthermia therapy in bladder cancer

Thomas A. Longo, Ajay Gopalakrishna, Matvey Tsivian, Megan Van Noord, Coen R. Rasch, Brant A. Inman, Elisabeth D. Geijsen

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations


Context: Bladder cancer therapy remains suboptimal as morbidity and mortality remain high amongst those with non-muscle-invasive and muscle-invasive disease. Regional hyperthermia therapy (RHT) is a promising adjunctive therapy being tested in multiple clinical contexts. Objective: The aim of this study was to systematically review the literature on the efficacy and toxicity of RHT. Evidence acquisition: This systematic review was registered with the PROSPERO database (Registration number: CRD42015025780) and was conducted according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. We queried PubMed, EMBASE, and Cochrane libraries. Two reviewers reviewed abstracts independently and a third reviewer arbitrated disagreements. The last search was performed on 28 August 2015. A descriptive analysis was performed and quality assessment was conducted using the Newcastle-Ottawa Quality Assessment Scale for observational studies, and the Cochrane Risk of Bias Assessment Tool for trials. Evidence synthesis: We identified 859 publications in the initial search, of which 24 met inclusion criteria for full-text review. Of these, we were able to obtain data on the outcomes of interest for 15 publications. Conclusions: The review underscores the limited nature of the evidence; definitive conclusions are elusive. However, the promising results of RHT in the setting of intravesical chemotherapy, chemotherapy and radiotherapy show a trend towards legitimate efficacy.

Original languageEnglish (US)
Pages (from-to)381-389
Number of pages9
JournalInternational Journal of Hyperthermia
Issue number4
StatePublished - May 18 2016
Externally publishedYes


  • Bladder cancer
  • chemohyperthermia
  • radiohyperthermia
  • regional hyperthermia therapy
  • urothelial carcinoma

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Cancer Research


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