A systematic review of regional hyperthermia therapy in bladder cancer

Thomas A. Longo, Ajay Gopalakrishna, Matvey Tsivian, Megan Van Noord, Coen R. Rasch, Brant A. Inman, Elisabeth D. Geijsen

Research output: Contribution to journalReview article

21 Citations (Scopus)

Abstract

Context: Bladder cancer therapy remains suboptimal as morbidity and mortality remain high amongst those with non-muscle-invasive and muscle-invasive disease. Regional hyperthermia therapy (RHT) is a promising adjunctive therapy being tested in multiple clinical contexts. Objective: The aim of this study was to systematically review the literature on the efficacy and toxicity of RHT. Evidence acquisition: This systematic review was registered with the PROSPERO database (Registration number: CRD42015025780) and was conducted according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. We queried PubMed, EMBASE, and Cochrane libraries. Two reviewers reviewed abstracts independently and a third reviewer arbitrated disagreements. The last search was performed on 28 August 2015. A descriptive analysis was performed and quality assessment was conducted using the Newcastle-Ottawa Quality Assessment Scale for observational studies, and the Cochrane Risk of Bias Assessment Tool for trials. Evidence synthesis: We identified 859 publications in the initial search, of which 24 met inclusion criteria for full-text review. Of these, we were able to obtain data on the outcomes of interest for 15 publications. Conclusions: The review underscores the limited nature of the evidence; definitive conclusions are elusive. However, the promising results of RHT in the setting of intravesical chemotherapy, chemotherapy and radiotherapy show a trend towards legitimate efficacy.

Original languageEnglish (US)
Pages (from-to)381-389
Number of pages9
JournalInternational Journal of Hyperthermia
Volume32
Issue number4
DOIs
StatePublished - May 18 2016
Externally publishedYes

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Urinary Bladder Neoplasms
Fever
Publications
Therapeutics
Drug Therapy
PubMed
Libraries
Observational Studies
Meta-Analysis
Radiotherapy
Databases
Guidelines
Morbidity
Muscles
Mortality

Keywords

  • Bladder cancer
  • chemohyperthermia
  • radiohyperthermia
  • regional hyperthermia therapy
  • urothelial carcinoma

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Cancer Research

Cite this

Longo, T. A., Gopalakrishna, A., Tsivian, M., Van Noord, M., Rasch, C. R., Inman, B. A., & Geijsen, E. D. (2016). A systematic review of regional hyperthermia therapy in bladder cancer. International Journal of Hyperthermia, 32(4), 381-389. https://doi.org/10.3109/02656736.2016.1157903

A systematic review of regional hyperthermia therapy in bladder cancer. / Longo, Thomas A.; Gopalakrishna, Ajay; Tsivian, Matvey; Van Noord, Megan; Rasch, Coen R.; Inman, Brant A.; Geijsen, Elisabeth D.

In: International Journal of Hyperthermia, Vol. 32, No. 4, 18.05.2016, p. 381-389.

Research output: Contribution to journalReview article

Longo, TA, Gopalakrishna, A, Tsivian, M, Van Noord, M, Rasch, CR, Inman, BA & Geijsen, ED 2016, 'A systematic review of regional hyperthermia therapy in bladder cancer', International Journal of Hyperthermia, vol. 32, no. 4, pp. 381-389. https://doi.org/10.3109/02656736.2016.1157903
Longo, Thomas A. ; Gopalakrishna, Ajay ; Tsivian, Matvey ; Van Noord, Megan ; Rasch, Coen R. ; Inman, Brant A. ; Geijsen, Elisabeth D. / A systematic review of regional hyperthermia therapy in bladder cancer. In: International Journal of Hyperthermia. 2016 ; Vol. 32, No. 4. pp. 381-389.
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