A systematic review of cost-effectiveness analyses of complex wound interventions reveals optimal treatments for specific wound types

Andrea C. Tricco, Elise Cogo, Wanrudee Isaranuwatchai, Paul A. Khan, Geetha Sanmugalingham, Jesmin Antony, Jeffrey S Hoch, Sharon E. Straus

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background: Complex wounds present a substantial economic burden on healthcare systems, costing billions of dollars annually in North America alone. The prevalence of complex wounds is a significant patient and societal healthcare concern and cost-effective wound care management remains unclear. This article summarizes the cost-effectiveness of interventions for complex wound care through a systematic review of the evidence base. Methods: We searched multiple databases (MEDLINE, EMBASE, Cochrane Library) for cost-effectiveness studies that examined adults treated for complex wounds. Two reviewers independently screened the literature, abstracted data from full-text articles, and assessed methodological quality using the Drummond 10-item methodological quality tool. Incremental cost-effectiveness ratios were reported, or, if not reported, calculated and converted to United States Dollars for the year 2013. Results: Overall, 59 cost-effectiveness analyses were included; 71% (42 out of 59) of the included studies scored 8 or more points on the Drummond 10-item checklist tool. Based on these, 22 interventions were found to be more effective and less costly (i.e., dominant) compared to the study comparators: 9 for diabetic ulcers, 8 for venous ulcers, 3 for pressure ulcers, 1 for mixed venous and venous/arterial ulcers, and 1 for mixed complex wound types. Conclusions: Our results can be used by decision-makers in maximizing the deployment of clinically effective and resource efficient wound care interventions. Our analysis also highlights specific treatments that are not cost-effective, thereby indicating areas of resource savings.

Original languageEnglish (US)
Article number90
JournalBMC Medicine
Volume13
Issue number1
DOIs
StatePublished - Apr 22 2015
Externally publishedYes

Fingerprint

Cost-Benefit Analysis
Wounds and Injuries
Varicose Ulcer
Health Care Costs
Therapeutics
Pressure Ulcer
North America
Checklist
MEDLINE
Libraries
Ulcer
Economics
Databases
Delivery of Health Care

Keywords

  • Complex wound
  • Cost-benefit analysis
  • Cost-effectiveness analysis
  • Research design
  • Skin ulcer
  • Systematic review

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Tricco, A. C., Cogo, E., Isaranuwatchai, W., Khan, P. A., Sanmugalingham, G., Antony, J., ... Straus, S. E. (2015). A systematic review of cost-effectiveness analyses of complex wound interventions reveals optimal treatments for specific wound types. BMC Medicine, 13(1), [90]. https://doi.org/10.1186/s12916-015-0326-3

A systematic review of cost-effectiveness analyses of complex wound interventions reveals optimal treatments for specific wound types. / Tricco, Andrea C.; Cogo, Elise; Isaranuwatchai, Wanrudee; Khan, Paul A.; Sanmugalingham, Geetha; Antony, Jesmin; Hoch, Jeffrey S; Straus, Sharon E.

In: BMC Medicine, Vol. 13, No. 1, 90, 22.04.2015.

Research output: Contribution to journalArticle

Tricco, Andrea C. ; Cogo, Elise ; Isaranuwatchai, Wanrudee ; Khan, Paul A. ; Sanmugalingham, Geetha ; Antony, Jesmin ; Hoch, Jeffrey S ; Straus, Sharon E. / A systematic review of cost-effectiveness analyses of complex wound interventions reveals optimal treatments for specific wound types. In: BMC Medicine. 2015 ; Vol. 13, No. 1.
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