A Synchronous IRF4-Dependent Gene Regulatory Network in B and Helper T Cells Orchestrating the Antibody Response

Sarah L. Cook; Marissa C. Franke; Evelyn P. Sievert; Roger Sciammas

doi:10.1016/j.it.2020.05.001

A Synchronous IRF4-Dependent Gene Regulatory Network in B and Helper T Cells Orchestrating the Antibody Response

Sarah L. Cook, Marissa C. Franke, Evelyn P. Sievert, Roger Sciammas

School of Veterinary Medicine

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Control of diverse pathogens requires an adaptive antibody response, dependent on cellular division of labor to allocate antigen-dependent B- and CD4⁺ T-cell fates that collaborate to control the quantity and quality of antibody. This is orchestrated by the dynamic action of key transcriptional regulators mediating gene expression programs in response to pathogen-specific environmental inputs. We describe a conserved, likely ancient, gene regulatory network that intriguingly operates contemporaneously in B and CD4⁺ T cells to control their cell fate dynamics and thus, the character of the antibody response. The remarkable output of this network derives from graded expression, designated by antigen receptor signal strength, of a pivotal transcription factor that regulates alternate cell fate choices.

Original language	English (US)
Journal	Trends in Immunology
DOIs	https://doi.org/10.1016/j.it.2020.05.001
State	Accepted/In press - Jan 1 2020

Keywords

antibody response
Bcl6
Blimp-1
cell differentiation
IRF4
transcription factors

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Access to Document

10.1016/j.it.2020.05.001

Fingerprint Dive into the research topics of 'A Synchronous IRF4-Dependent Gene Regulatory Network in B and Helper T Cells Orchestrating the Antibody Response'. Together they form a unique fingerprint.

Cite this

@article{05e977de3168454f832db21005a03192,

title = "A Synchronous IRF4-Dependent Gene Regulatory Network in B and Helper T Cells Orchestrating the Antibody Response",

abstract = "Control of diverse pathogens requires an adaptive antibody response, dependent on cellular division of labor to allocate antigen-dependent B- and CD4+ T-cell fates that collaborate to control the quantity and quality of antibody. This is orchestrated by the dynamic action of key transcriptional regulators mediating gene expression programs in response to pathogen-specific environmental inputs. We describe a conserved, likely ancient, gene regulatory network that intriguingly operates contemporaneously in B and CD4+ T cells to control their cell fate dynamics and thus, the character of the antibody response. The remarkable output of this network derives from graded expression, designated by antigen receptor signal strength, of a pivotal transcription factor that regulates alternate cell fate choices.",

keywords = "antibody response, Bcl6, Blimp-1, cell differentiation, IRF4, transcription factors",

author = "Cook, {Sarah L.} and Franke, {Marissa C.} and Sievert, {Evelyn P.} and Roger Sciammas",

year = "2020",

month = jan,

day = "1",

doi = "10.1016/j.it.2020.05.001",

language = "English (US)",

journal = "Trends in Immunology",

issn = "1471-4906",

publisher = "Elsevier Limited",

}

TY - JOUR

T1 - A Synchronous IRF4-Dependent Gene Regulatory Network in B and Helper T Cells Orchestrating the Antibody Response

AU - Cook, Sarah L.

AU - Franke, Marissa C.

AU - Sievert, Evelyn P.

AU - Sciammas, Roger

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Control of diverse pathogens requires an adaptive antibody response, dependent on cellular division of labor to allocate antigen-dependent B- and CD4+ T-cell fates that collaborate to control the quantity and quality of antibody. This is orchestrated by the dynamic action of key transcriptional regulators mediating gene expression programs in response to pathogen-specific environmental inputs. We describe a conserved, likely ancient, gene regulatory network that intriguingly operates contemporaneously in B and CD4+ T cells to control their cell fate dynamics and thus, the character of the antibody response. The remarkable output of this network derives from graded expression, designated by antigen receptor signal strength, of a pivotal transcription factor that regulates alternate cell fate choices.

AB - Control of diverse pathogens requires an adaptive antibody response, dependent on cellular division of labor to allocate antigen-dependent B- and CD4+ T-cell fates that collaborate to control the quantity and quality of antibody. This is orchestrated by the dynamic action of key transcriptional regulators mediating gene expression programs in response to pathogen-specific environmental inputs. We describe a conserved, likely ancient, gene regulatory network that intriguingly operates contemporaneously in B and CD4+ T cells to control their cell fate dynamics and thus, the character of the antibody response. The remarkable output of this network derives from graded expression, designated by antigen receptor signal strength, of a pivotal transcription factor that regulates alternate cell fate choices.

KW - antibody response

KW - Bcl6

KW - Blimp-1

KW - cell differentiation

KW - IRF4

KW - transcription factors

UR - http://www.scopus.com/inward/record.url?scp=85085284899&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85085284899&partnerID=8YFLogxK

U2 - 10.1016/j.it.2020.05.001

DO - 10.1016/j.it.2020.05.001

M3 - Review article

C2 - 32467029

AN - SCOPUS:85085284899

JO - Trends in Immunology

JF - Trends in Immunology

SN - 1471-4906

ER -

A Synchronous IRF4-Dependent Gene Regulatory Network in B and Helper T Cells Orchestrating the Antibody Response

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this