A surface-modified chylomicron remnant-like emulsion for percutaneous computed tomography lymphography: Synthesis and preliminary imaging findings

Erik R Wisner, Jamey P. Weichert, Marc A. Longino, Raymond E. Counsell, Stephen E. Weisbrode

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

RATIONALE AND OBJECTIVES. To assess a surface-modified emulsion as a percutaneous CT lymphographic agent in normal dogs. METHODS. An iodinated chylomicron remnant-like micro-emulsion was formulated with a mean particle size of 91.3 nm and an iodine concentration of 91 mg I/mL. Contrast material (2 mL) was injected into the subcutaneous tissues of the metatarsus and metacarpus of six normal dogs to enhance popliteal and cervical lymph nodes, respectively. CT images were acquired at 0, 15, 30, 45, 60, 240, 480, and 1440 minutes. RESULTS. Significant lymph node enhancement occurred in as little as 15 minutes after injection and persisted at least 8 hours. Node opacification was most pronounced at 1 to 4 hours postinjection and exceeded 200 HU in some nodes (precontrast attenuation = 45 HU). Marked enhancement of popliteal efferent lymphatics and of iliac and sacral node groups also occurred indicating distribution to second order nodes. Attenuation of enhanced nodes reverted to precontrast levels by 24 hours. CONCLUSION. The new surface-modified, chylomicron remnant-like emulsion provided marked, selective enhancement of targeted lymph nodes after subcutaneous administration. Moreover, the formulation produced significant opacification of more distant node groups from a single injection.

Original languageEnglish (US)
Pages (from-to)232-239
Number of pages8
JournalInvestigative Radiology
Volume37
Issue number4
DOIs
StatePublished - 2002

Keywords

  • Chylomicron
  • Contrast media
  • Experimental studies, CT
  • Iodinated microemulsion
  • Lymphatic system, CT
  • Lymphography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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