A subpopulation of the v-erb A oncogene protein, a derivative of a thyroid hormone receptor, associates with heat shock protein 90

Martin L. Privalsky

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

The v-erb A oncogene of avian erythroblastosis virus is derived from a host gene for a thyroid hormone receptor and is able to block differentiation of erythroid cells and modify the growth properties of fibroblasts. Unlike its host cell progenitor, the v-erb A protein is found in both cytoplasmic and nuclear fractions of the cell. I report here that the cytoplasmic form of the v-erb A protein is associated in a higher molecular weight complex with heat shock protein 90, the same polypeptide found in association with the unliganded steroid receptors and with the soluble forms of the src oncogene.

Original languageEnglish (US)
Pages (from-to)1456-1462
Number of pages7
JournalJournal of Biological Chemistry
Volume266
Issue number3
StatePublished - Jan 25 1991

ASJC Scopus subject areas

  • Biochemistry

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