A subpopulation of primate corticocortical neurons is distinguished by somatodendritic distribution of neurofilament protein

Michael J. Campbell, Patrick R. Hof, John Morrison

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

In recent immunohistochemical studies of human and monkey neocortex we observed that the somatodendritic distribution of neurofilament protein appears to be restricted to a subpopulation of pyramidal neurons. To further characterize this apparent specificity in cytoskeletal organization, combined retrograde tract tracing and immunohistochemical methods were used to examine the extent to which neurons from different cortical areas providing a projection to prefrontal cortex have a somatodendritic distribution of neurofilament proteins. These studies revealed that the proportion of neurons providing a projection from different cortical areas to prefrontal cortex varied from nearly 30% to 90%, and appeared to be related to the functional nature of the projection.

Original languageEnglish (US)
Pages (from-to)133-136
Number of pages4
JournalBrain Research
Volume539
Issue number1
DOIs
StatePublished - Jan 18 1991
Externally publishedYes

Fingerprint

Neurofilament Proteins
Prefrontal Cortex
Primates
Neurons
Pyramidal Cells
Neocortex
Haplorhini

Keywords

  • Corticocortical connection
  • Cytoskeleton
  • Monkey
  • Neurofilament protein
  • Pyramidal neuron

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

A subpopulation of primate corticocortical neurons is distinguished by somatodendritic distribution of neurofilament protein. / Campbell, Michael J.; Hof, Patrick R.; Morrison, John.

In: Brain Research, Vol. 539, No. 1, 18.01.1991, p. 133-136.

Research output: Contribution to journalArticle

@article{9337a2d63ff04cc2940fa98fb4000d0b,
title = "A subpopulation of primate corticocortical neurons is distinguished by somatodendritic distribution of neurofilament protein",
abstract = "In recent immunohistochemical studies of human and monkey neocortex we observed that the somatodendritic distribution of neurofilament protein appears to be restricted to a subpopulation of pyramidal neurons. To further characterize this apparent specificity in cytoskeletal organization, combined retrograde tract tracing and immunohistochemical methods were used to examine the extent to which neurons from different cortical areas providing a projection to prefrontal cortex have a somatodendritic distribution of neurofilament proteins. These studies revealed that the proportion of neurons providing a projection from different cortical areas to prefrontal cortex varied from nearly 30{\%} to 90{\%}, and appeared to be related to the functional nature of the projection.",
keywords = "Corticocortical connection, Cytoskeleton, Monkey, Neurofilament protein, Pyramidal neuron",
author = "Campbell, {Michael J.} and Hof, {Patrick R.} and John Morrison",
year = "1991",
month = "1",
day = "18",
doi = "10.1016/0006-8993(91)90695-R",
language = "English (US)",
volume = "539",
pages = "133--136",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - A subpopulation of primate corticocortical neurons is distinguished by somatodendritic distribution of neurofilament protein

AU - Campbell, Michael J.

AU - Hof, Patrick R.

AU - Morrison, John

PY - 1991/1/18

Y1 - 1991/1/18

N2 - In recent immunohistochemical studies of human and monkey neocortex we observed that the somatodendritic distribution of neurofilament protein appears to be restricted to a subpopulation of pyramidal neurons. To further characterize this apparent specificity in cytoskeletal organization, combined retrograde tract tracing and immunohistochemical methods were used to examine the extent to which neurons from different cortical areas providing a projection to prefrontal cortex have a somatodendritic distribution of neurofilament proteins. These studies revealed that the proportion of neurons providing a projection from different cortical areas to prefrontal cortex varied from nearly 30% to 90%, and appeared to be related to the functional nature of the projection.

AB - In recent immunohistochemical studies of human and monkey neocortex we observed that the somatodendritic distribution of neurofilament protein appears to be restricted to a subpopulation of pyramidal neurons. To further characterize this apparent specificity in cytoskeletal organization, combined retrograde tract tracing and immunohistochemical methods were used to examine the extent to which neurons from different cortical areas providing a projection to prefrontal cortex have a somatodendritic distribution of neurofilament proteins. These studies revealed that the proportion of neurons providing a projection from different cortical areas to prefrontal cortex varied from nearly 30% to 90%, and appeared to be related to the functional nature of the projection.

KW - Corticocortical connection

KW - Cytoskeleton

KW - Monkey

KW - Neurofilament protein

KW - Pyramidal neuron

UR - http://www.scopus.com/inward/record.url?scp=0026029966&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026029966&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(91)90695-R

DO - 10.1016/0006-8993(91)90695-R

M3 - Article

C2 - 1707737

AN - SCOPUS:0026029966

VL - 539

SP - 133

EP - 136

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1

ER -