A study of radiation necrosis and edema in the canine brain using positron emission tomography and magnetic resonance imaging

K. M. Brennan, M. S. Roos, T. F. Budinger, Robert Higgins, S. T.S. Wong, K. S. Bristol

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Radiation injury, a major hazard of central nervous system (CNS) radiotherapy, was investigated using sequential studies with positron emission tomography (PET) and magnetic resonance imaging (MRI) in beagle dogs with both helium and neon-ion hemibrain irradiation. All dogs receiving 7.5- 11 Gy of neon showed no signs of radiation injury to 3 years after irradiation. Dogs receiving ≥13 Gy neon or helium succumbed to radiation necrosis and died 21-32 weeks after irradiation. The findings of imaging studies for all dogs who succumbed to radiation necrosis were normal until 3- 6 weeks before death. Sequential studies were performed using 0.5 T MRI spin- echo and inversion recovery imaging sequences, and high-resolution (2-3 mm) PET with 18F deoxyglucose and 82Rb. The same axial slices (within 1-2 mm) were imaged repeatedly (weekly) after irradiation until death. The earliest CNS changes were seen as decreased metabolic activity in the cortex of the irradiated hemisphere with PET or an increase in signal intensity in the periventricular white matter on T2-weighted spin-echo imaging on MRI. From the time this increase in signal intensity was first observed, T1 and T2 values increased steadily in both the gray and white matter until death. The changes in white matter were consistently greater than those in gray matter. The results of PET, MRI, and histopathological examinations support the theory that both cellular and vascular mechanisms are involved in radiation necrosis.

Original languageEnglish (US)
Pages (from-to)43-53
Number of pages11
JournalRadiation Research
Volume134
Issue number1
DOIs
StatePublished - Jun 8 1993
Externally publishedYes

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edema
dogs
necrosis
Positron-Emission Tomography
brain
magnetic resonance
Canidae
positrons
Neon
Edema
Necrosis
tomography
Magnetic Resonance Imaging
death
neon
Radiation
radiation injuries
central nervous system
Dogs
Brain

ASJC Scopus subject areas

  • Biophysics
  • Radiation
  • Radiology Nuclear Medicine and imaging

Cite this

A study of radiation necrosis and edema in the canine brain using positron emission tomography and magnetic resonance imaging. / Brennan, K. M.; Roos, M. S.; Budinger, T. F.; Higgins, Robert; Wong, S. T.S.; Bristol, K. S.

In: Radiation Research, Vol. 134, No. 1, 08.06.1993, p. 43-53.

Research output: Contribution to journalArticle

Brennan, K. M. ; Roos, M. S. ; Budinger, T. F. ; Higgins, Robert ; Wong, S. T.S. ; Bristol, K. S. / A study of radiation necrosis and edema in the canine brain using positron emission tomography and magnetic resonance imaging. In: Radiation Research. 1993 ; Vol. 134, No. 1. pp. 43-53.
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