125I-insulin binding to erythrocytes were compared between 19 Indian and African healthy volunteers matched for age, sex and body mass index. There were no significant differences in 125I-insulin binding between Indians and Africans (maximum specific binding 9.13 ± 0.52% and 8.74 ± 0.51% respectively, p = 0.29). However, when 125I-insulin binding was compared between 16 males and females matched for age and body mass index, the males had significantly higher specific binding than the females (maximum specific binding 9.8 ± 0.6% and 7.9 ± 0.4% respectively, p < 0.01). This difference in binding was due to a lower receptor number in females as evidence by Scatchard analysis; ID50 values revealed similar receptor affinities. In conclusion, while there is no difference in receptor binding between Indians and Africans, males have significantly higher specific binding than females.
|Original language||English (US)|
|Number of pages||4|
|State||Published - 1987|
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Internal Medicine