A study of erythrocyte insulin receptors in normal Indian and African volunteers

I. Jialal, M. Naiker, T. Govender, S. M. Joubert

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

125I-insulin binding to erythrocytes were compared between 19 Indian and African healthy volunteers matched for age, sex and body mass index. There were no significant differences in 125I-insulin binding between Indians and Africans (maximum specific binding 9.13 ± 0.52% and 8.74 ± 0.51% respectively, p = 0.29). However, when 125I-insulin binding was compared between 16 males and females matched for age and body mass index, the males had significantly higher specific binding than the females (maximum specific binding 9.8 ± 0.6% and 7.9 ± 0.4% respectively, p < 0.01). This difference in binding was due to a lower receptor number in females as evidence by Scatchard analysis; ID50 values revealed similar receptor affinities. In conclusion, while there is no difference in receptor binding between Indians and Africans, males have significantly higher specific binding than females.

Original languageEnglish (US)
Pages (from-to)35-38
Number of pages4
JournalDiabetes Research
Volume5
Issue number1
StatePublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

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    Jialal, I., Naiker, M., Govender, T., & Joubert, S. M. (1987). A study of erythrocyte insulin receptors in normal Indian and African volunteers. Diabetes Research, 5(1), 35-38.