Abstract
(Chemical Equation Presented) A short, linear sequence for the synthesis of complex small polycyclic lactams (see picture) is presented. The sequence, which is applied to the synthesis of a library of 529 compounds, is based on a catalytic, enantioselective cycloaddition between an oxazole and an aldehyde, so that the resultant compounds are enantiomerically pure and readily prepared in either stereochemical series.
Original language | English (US) |
---|---|
Pages (from-to) | 1722-1726 |
Number of pages | 5 |
Journal | Angewandte Chemie - International Edition |
Volume | 45 |
Issue number | 11 |
DOIs | |
State | Published - Mar 3 2006 |
Externally published | Yes |
Keywords
- Asymmetric synthesis
- Combinatorial chemistry
- Lactams
- Synthetic methods
ASJC Scopus subject areas
- Chemistry(all)