A structurally diverse library of polycyclic lactams resulting from systematic placement of proximal functional groups

Judith M. Mitchell; Jared T. Shaw

doi:10.1002/anie.200503341

A structurally diverse library of polycyclic lactams resulting from systematic placement of proximal functional groups

Judith M. Mitchell, Jared T. Shaw

Research output: Contribution to journal › Article

58 Scopus citations

Abstract

(Chemical Equation Presented) A short, linear sequence for the synthesis of complex small polycyclic lactams (see picture) is presented. The sequence, which is applied to the synthesis of a library of 529 compounds, is based on a catalytic, enantioselective cycloaddition between an oxazole and an aldehyde, so that the resultant compounds are enantiomerically pure and readily prepared in either stereochemical series.

Original language	English (US)
Pages (from-to)	1722-1726
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	45
Issue number	11
DOIs	https://doi.org/10.1002/anie.200503341
Publication status	Published - Mar 3 2006
Externally published	Yes

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Keywords

Asymmetric synthesis
Combinatorial chemistry
Lactams
Synthetic methods

ASJC Scopus subject areas

Chemistry(all)

Cite this

Mitchell, J. M., & Shaw, J. T. (2006). A structurally diverse library of polycyclic lactams resulting from systematic placement of proximal functional groups. Angewandte Chemie - International Edition, 45(11), 1722-1726. https://doi.org/10.1002/anie.200503341

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Access to Document

10.1002/anie.200503341