A structurally diverse library of polycyclic lactams resulting from systematic placement of proximal functional groups

Judith M. Mitchell, Jared T. Shaw

Research output: Contribution to journalArticle

58 Scopus citations


(Chemical Equation Presented) A short, linear sequence for the synthesis of complex small polycyclic lactams (see picture) is presented. The sequence, which is applied to the synthesis of a library of 529 compounds, is based on a catalytic, enantioselective cycloaddition between an oxazole and an aldehyde, so that the resultant compounds are enantiomerically pure and readily prepared in either stereochemical series.

Original languageEnglish (US)
Pages (from-to)1722-1726
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number11
Publication statusPublished - Mar 3 2006
Externally publishedYes



  • Asymmetric synthesis
  • Combinatorial chemistry
  • Lactams
  • Synthetic methods

ASJC Scopus subject areas

  • Chemistry(all)

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