A structurally diverse library of polycyclic lactams resulting from systematic placement of proximal functional groups

Judith M. Mitchell, Jared T. Shaw

Research output: Contribution to journalArticle

58 Scopus citations

Abstract

(Chemical Equation Presented) A short, linear sequence for the synthesis of complex small polycyclic lactams (see picture) is presented. The sequence, which is applied to the synthesis of a library of 529 compounds, is based on a catalytic, enantioselective cycloaddition between an oxazole and an aldehyde, so that the resultant compounds are enantiomerically pure and readily prepared in either stereochemical series.

Original languageEnglish (US)
Pages (from-to)1722-1726
Number of pages5
JournalAngewandte Chemie - International Edition
Volume45
Issue number11
DOIs
StatePublished - Mar 3 2006
Externally publishedYes

Keywords

  • Asymmetric synthesis
  • Combinatorial chemistry
  • Lactams
  • Synthetic methods

ASJC Scopus subject areas

  • Chemistry(all)

Fingerprint Dive into the research topics of 'A structurally diverse library of polycyclic lactams resulting from systematic placement of proximal functional groups'. Together they form a unique fingerprint.

  • Cite this