Abstract
(Chemical Equation Presented) A short, linear sequence for the synthesis of complex small polycyclic lactams (see picture) is presented. The sequence, which is applied to the synthesis of a library of 529 compounds, is based on a catalytic, enantioselective cycloaddition between an oxazole and an aldehyde, so that the resultant compounds are enantiomerically pure and readily prepared in either stereochemical series.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1722-1726 |
| Number of pages | 5 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 45 |
| Issue number | 11 |
| DOIs | |
| State | Published - Mar 3 2006 |
| Externally published | Yes |
Keywords
- Asymmetric synthesis
- Combinatorial chemistry
- Lactams
- Synthetic methods
ASJC Scopus subject areas
- Chemistry(all)
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Mitchell, J. M., & Shaw, J. T. (2006). A structurally diverse library of polycyclic lactams resulting from systematic placement of proximal functional groups. Angewandte Chemie - International Edition, 45(11), 1722-1726. https://doi.org/10.1002/anie.200503341