A monoclonal antibody elicited by a transition-state analog that is representative of an intramolecular six-membercd ring cyclization reaction acted as a stercospecific, enzyme-like catalyst for the appropriate substrate. Formation of a single enantiomer of a 5-lactone from the corresponding racemic 8-hydroxyester was accelerated by the antibody by about a factor of 170, which permitted isolation of the lactone in an enantiomeric excess of about 94 percent. This finding demonstrates the feasibility of catalytic-antibody generation for chemical transformations that require stereochemical control.
|Original language||English (US)|
|Number of pages||3|
|State||Published - 1987|
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