A spoonful of sugar: Feedback signals of energy stores and corticosterone regulate responses to chronic stress

Mary F. Dallman, Susan F. Akana, Kevin D. Laugero, Francisca Gomez, Sotara Manalo, M. E. Bell, Seema Bhatnagar

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

To begin to understand the effects of chronic stress on food intake and energy stores, the effects of increased activity in the hypothalamo-pituitary-adrenal (HPA) axis and glucocorticoids (GCs) on the body and brain must first be understood. We propose two major systems that are both GC sensitive: a metabolic feedback that is inhibitory and a direct central GC drive. Under basal conditions, the metabolic feedback signal to brain is dominant, although infusion of GC into a lateral brain ventricle blocks the effects of the metabolic feedback. Chronic stress activates GC secretion and brain nuclear GC receptor occupancy, markedly changing the normal relationships between these two major corticosteroid-activated systems. The stressor-induced switch in the relative strengths of these signals determines subsequent brain regulation of stress responses (behavioral, neuroendocrine and autonomic outflows). The metabolic feedback effects of GCs are mimicked by voluntary sucrose ingestion in adrenalectomized rats, and experiments suggest that the metabolic feedback also inhibits the stressor-induced direct GC drive on brain. We speculate that the interaction between peripheral and central GC-sensitive signaling systems may be coupled through the inhibitory actions of endogenous opiatergic inputs on corticotropin-releasing factor (CRF) neurons.

Original languageEnglish (US)
Pages (from-to)3-12
Number of pages10
JournalPhysiology and Behavior
Volume79
Issue number1
DOIs
StatePublished - Jun 2003
Externally publishedYes

Fingerprint

Corticosterone
Glucocorticoids
Brain
Eating
Lateral Ventricles
Corticotropin-Releasing Hormone
Glucocorticoid Receptors
Cytoplasmic and Nuclear Receptors
Sucrose
Adrenal Cortex Hormones
Neurons

Keywords

  • Chronic stress
  • Corticosterone
  • Energy stores
  • Food intake

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Physiology (medical)

Cite this

Dallman, M. F., Akana, S. F., Laugero, K. D., Gomez, F., Manalo, S., Bell, M. E., & Bhatnagar, S. (2003). A spoonful of sugar: Feedback signals of energy stores and corticosterone regulate responses to chronic stress. Physiology and Behavior, 79(1), 3-12. https://doi.org/10.1016/S0031-9384(03)00100-8

A spoonful of sugar : Feedback signals of energy stores and corticosterone regulate responses to chronic stress. / Dallman, Mary F.; Akana, Susan F.; Laugero, Kevin D.; Gomez, Francisca; Manalo, Sotara; Bell, M. E.; Bhatnagar, Seema.

In: Physiology and Behavior, Vol. 79, No. 1, 06.2003, p. 3-12.

Research output: Contribution to journalArticle

Dallman, MF, Akana, SF, Laugero, KD, Gomez, F, Manalo, S, Bell, ME & Bhatnagar, S 2003, 'A spoonful of sugar: Feedback signals of energy stores and corticosterone regulate responses to chronic stress', Physiology and Behavior, vol. 79, no. 1, pp. 3-12. https://doi.org/10.1016/S0031-9384(03)00100-8
Dallman, Mary F. ; Akana, Susan F. ; Laugero, Kevin D. ; Gomez, Francisca ; Manalo, Sotara ; Bell, M. E. ; Bhatnagar, Seema. / A spoonful of sugar : Feedback signals of energy stores and corticosterone regulate responses to chronic stress. In: Physiology and Behavior. 2003 ; Vol. 79, No. 1. pp. 3-12.
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