A smart and versatile theranostic nanomedicine platform based on nanoporphyrin

Yuanpei Li, Tzu-Yin Lin, Yan Luo, Qiangqiang Liu, Wenwu Xiao, Wenchang Guo, Diana Lac, Hongyong Zhang, Caihong Feng, Sebastian Wachsmann-Hogiu, Jeffrey H. Walton, Simon R Cherry, Douglas J. Rowland, David Kukis, Chong-Xian Pan, Kit Lam

Research output: Contribution to journalArticle

209 Citations (Scopus)

Abstract

Multifunctional nanoparticles with combined diagnostic and therapeutic functions show great promise towards personalized nanomedicine. However, attaining consistently high performance of these functions in vivo in one single nanoconstruct remains extremely challenging. Here we demonstrate the use of one single polymer to develop a smart 'all-in-one' nanoporphyrin platform that conveniently integrates a broad range of clinically relevant functions. Nanoporphyrins can be used as amplifiable multimodality nanoprobes for near-infrared fluorescence imaging (NIRFI), magnetic resonance imaging (MRI), positron emission tomography (PET) and dual modal PET-MRI. Nanoporphyrins greatly increase the imaging sensitivity for tumour detection through background suppression in blood, as well as preferential accumulation and signal amplification in tumours. Nanoporphyrins also function as multiphase nanotransducers that can efficiently convert light to heat inside tumours for photothermal therapy (PTT), and light to singlet oxygen for photodynamic therapy (PDT). Furthermore, nanoporphyrins act as programmable releasing nanocarriers for targeted delivery of drugs or therapeutic radio-metals into tumours.

Original languageEnglish (US)
Article number4712
JournalNature Communications
Volume5
DOIs
StatePublished - Aug 26 2014

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Medical nanotechnology
Tumors
tumors
platforms
Imaging techniques
Positron emission tomography
Magnetic resonance
Positron-Emission Tomography
magnetic resonance
therapy
positrons
Neoplasms
tomography
Magnetic Resonance Imaging
Nanomedicine
Nanoprobes
Light
Singlet Oxygen
Photodynamic therapy
Optical Imaging

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry(all)
  • Physics and Astronomy(all)

Cite this

A smart and versatile theranostic nanomedicine platform based on nanoporphyrin. / Li, Yuanpei; Lin, Tzu-Yin; Luo, Yan; Liu, Qiangqiang; Xiao, Wenwu; Guo, Wenchang; Lac, Diana; Zhang, Hongyong; Feng, Caihong; Wachsmann-Hogiu, Sebastian; Walton, Jeffrey H.; Cherry, Simon R; Rowland, Douglas J.; Kukis, David; Pan, Chong-Xian; Lam, Kit.

In: Nature Communications, Vol. 5, 4712, 26.08.2014.

Research output: Contribution to journalArticle

Li, Yuanpei ; Lin, Tzu-Yin ; Luo, Yan ; Liu, Qiangqiang ; Xiao, Wenwu ; Guo, Wenchang ; Lac, Diana ; Zhang, Hongyong ; Feng, Caihong ; Wachsmann-Hogiu, Sebastian ; Walton, Jeffrey H. ; Cherry, Simon R ; Rowland, Douglas J. ; Kukis, David ; Pan, Chong-Xian ; Lam, Kit. / A smart and versatile theranostic nanomedicine platform based on nanoporphyrin. In: Nature Communications. 2014 ; Vol. 5.
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