A single targeted Ets2 allele restricts development of mammary tumors in transgenic mice

Nickolay Neznanov, Albert K. Man, Hideyuki Yamamoto, Craig A. Hauser, Robert Cardiff, Robert G. Oshima

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

Heterozygous female mice carrying a targeted mutation of the Ets2 transcription factor gene were mated with a mouse strain that develops mammary tumors due to the expression of the polyoma virus middle T oncogene. Tumors from females with only one wild-type Ets2 gene were approximately one- half the size of tumors from controls. The smaller size of the tumors was correlated with a more differentiated state of early hyperplastic growths and not to differential growth of the frank tumors or to decreased middle T gene expression. Ets2 may regulate the progression of these aggressive mammary tumors.

Original languageEnglish (US)
Pages (from-to)4242-4246
Number of pages5
JournalCancer Research
Volume59
Issue number17
StatePublished - Sep 1 1999

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Neznanov, N., Man, A. K., Yamamoto, H., Hauser, C. A., Cardiff, R., & Oshima, R. G. (1999). A single targeted Ets2 allele restricts development of mammary tumors in transgenic mice. Cancer Research, 59(17), 4242-4246.