A single targeted Ets2 allele restricts development of mammary tumors in transgenic mice

Nickolay Neznanov, Albert K. Man, Hideyuki Yamamoto, Craig A. Hauser, Robert Cardiff, Robert G. Oshima

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Heterozygous female mice carrying a targeted mutation of the Ets2 transcription factor gene were mated with a mouse strain that develops mammary tumors due to the expression of the polyoma virus middle T oncogene. Tumors from females with only one wild-type Ets2 gene were approximately one- half the size of tumors from controls. The smaller size of the tumors was correlated with a more differentiated state of early hyperplastic growths and not to differential growth of the frank tumors or to decreased middle T gene expression. Ets2 may regulate the progression of these aggressive mammary tumors.

Original languageEnglish (US)
Pages (from-to)4242-4246
Number of pages5
JournalCancer Research
Volume59
Issue number17
StatePublished - Sep 1 1999

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Transgenic Mice
Alleles
Breast Neoplasms
Neoplasms
Polyomavirus
Growth
Oncogenes
Genes
Transcription Factors
Gene Expression
Mutation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Neznanov, N., Man, A. K., Yamamoto, H., Hauser, C. A., Cardiff, R., & Oshima, R. G. (1999). A single targeted Ets2 allele restricts development of mammary tumors in transgenic mice. Cancer Research, 59(17), 4242-4246.

A single targeted Ets2 allele restricts development of mammary tumors in transgenic mice. / Neznanov, Nickolay; Man, Albert K.; Yamamoto, Hideyuki; Hauser, Craig A.; Cardiff, Robert; Oshima, Robert G.

In: Cancer Research, Vol. 59, No. 17, 01.09.1999, p. 4242-4246.

Research output: Contribution to journalArticle

Neznanov, N, Man, AK, Yamamoto, H, Hauser, CA, Cardiff, R & Oshima, RG 1999, 'A single targeted Ets2 allele restricts development of mammary tumors in transgenic mice', Cancer Research, vol. 59, no. 17, pp. 4242-4246.
Neznanov N, Man AK, Yamamoto H, Hauser CA, Cardiff R, Oshima RG. A single targeted Ets2 allele restricts development of mammary tumors in transgenic mice. Cancer Research. 1999 Sep 1;59(17):4242-4246.
Neznanov, Nickolay ; Man, Albert K. ; Yamamoto, Hideyuki ; Hauser, Craig A. ; Cardiff, Robert ; Oshima, Robert G. / A single targeted Ets2 allele restricts development of mammary tumors in transgenic mice. In: Cancer Research. 1999 ; Vol. 59, No. 17. pp. 4242-4246.
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