A single meal has the potential to alter brain oxylipin content

J. E. Norman, H. H. Aung, Y. Otoki, Z. Zhang, A. Y. Taha, J. C. Rutledge

Research output: Contribution to journalArticle


Our objective was to determine whether consumption of a single meal has the potential to alter brain oxylipin content. We examined the cerebrum of mice fed a single high-fat/high-sucrose Western meal or a low-fat/low-sucrose control meal, as well as fasted mice. We found no changes in fatty acid composition of cerebrum across the groups. The cerebral oxylipin profile of mice fed a Western meal is distinct from the profile of mice fed a low-fat/low-sucrose meal. Cerebral gene expression of cyclooxygenase 1, cyclooxygenase 2, and epoxide hydrolase 1 were elevated in Western meal-fed mice compared to low-fat/low-sucrose meal-fed mice. Mice that consumed either meal had lower gene expression of cytochrome P450, family 2, subfamily j, polypeptide 12 than fasted mice. Our data in this hypothesis-generating study indicates that the composition of a single meal has the potential to alter brain oxylipins and the gene expression of the enzymes responsible for their production.

Original languageEnglish (US)
Article number102062
JournalProstaglandins Leukotrienes and Essential Fatty Acids
StatePublished - Mar 2020



  • Brain
  • Fasting
  • Fatty acids
  • Meal consumption
  • Oxylipins
  • Western diet

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology

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