A single intake of a resveratrol-arginine conjugate improves microvascular function compared to trans-resveratrol in postmenopausal women

Dragana Djurica, Jingyan Ren, Roberta R. Holt, Xianchao Feng, Charles R. Carlson, Alan W Shindel, Carl L Keen, Robert M. Hackman

Research output: Contribution to journalArticle

Abstract

Resveratrol supplementation has been reported to improve markers of vascular function, but poor bioavailability of the parent compound is thought to limits its use. In this study, we compared the effects of a resveratrol-arginine conjugate (ResArg) to trans-resveratrol (trans-Res), the standard form used in supplements, on measures of microvascular function 1 h and 2 h after intake. Postmenopausal women were assigned to consume 90 mg of resveratrol as either ResArg or t-Res, in a double-blind, randomized, crossover design, at least one week apart. Microvascular function was assessed by peripheral arterial tonometry, and calculated as the reactive hyperemia index (RHI) and the Framingham RHI (fRHI); at 1 h, platelet reactivity, plasma resveratrol and nitrate/nitrite levels were also measured. A significant increase in fRHI was observed 1 h after intake of ResArg compared to trans-Res. Significant reductions in platelet reactivity were noted 1 h after ResArg intake, but not for trans-Res. Plasma resveratrol levels were increased 30 and 60 min after the consumption of both ResArg and t-Res. The results suggest a more rapid and pronounced response from ResArg than trans-Res on certain markers of vascular function.

Original languageEnglish (US)
Pages (from-to)132-138
Number of pages7
JournalPharmaNutrition
Volume4
Issue number3
DOIs
StatePublished - Jul 1 2016

Fingerprint

resveratrol
arginine
Arginine
Hyperemia
blood vessels
Blood Vessels
Blood Platelets
Manometry
Nitrites
Nitrates
Cross-Over Studies
nitrites
Biological Availability
bioavailability
nitrates

Keywords

  • Cardiovascular
  • Nitrate/nitrite
  • Platelets
  • Resveratrol
  • Vascular function

ASJC Scopus subject areas

  • Food Science
  • Pharmacology
  • Pharmacology (medical)

Cite this

A single intake of a resveratrol-arginine conjugate improves microvascular function compared to trans-resveratrol in postmenopausal women. / Djurica, Dragana; Ren, Jingyan; Holt, Roberta R.; Feng, Xianchao; Carlson, Charles R.; Shindel, Alan W; Keen, Carl L; Hackman, Robert M.

In: PharmaNutrition, Vol. 4, No. 3, 01.07.2016, p. 132-138.

Research output: Contribution to journalArticle

Djurica, Dragana ; Ren, Jingyan ; Holt, Roberta R. ; Feng, Xianchao ; Carlson, Charles R. ; Shindel, Alan W ; Keen, Carl L ; Hackman, Robert M. / A single intake of a resveratrol-arginine conjugate improves microvascular function compared to trans-resveratrol in postmenopausal women. In: PharmaNutrition. 2016 ; Vol. 4, No. 3. pp. 132-138.
@article{1531beb70b9c4b87a7962795c81a461b,
title = "A single intake of a resveratrol-arginine conjugate improves microvascular function compared to trans-resveratrol in postmenopausal women",
abstract = "Resveratrol supplementation has been reported to improve markers of vascular function, but poor bioavailability of the parent compound is thought to limits its use. In this study, we compared the effects of a resveratrol-arginine conjugate (ResArg) to trans-resveratrol (trans-Res), the standard form used in supplements, on measures of microvascular function 1 h and 2 h after intake. Postmenopausal women were assigned to consume 90 mg of resveratrol as either ResArg or t-Res, in a double-blind, randomized, crossover design, at least one week apart. Microvascular function was assessed by peripheral arterial tonometry, and calculated as the reactive hyperemia index (RHI) and the Framingham RHI (fRHI); at 1 h, platelet reactivity, plasma resveratrol and nitrate/nitrite levels were also measured. A significant increase in fRHI was observed 1 h after intake of ResArg compared to trans-Res. Significant reductions in platelet reactivity were noted 1 h after ResArg intake, but not for trans-Res. Plasma resveratrol levels were increased 30 and 60 min after the consumption of both ResArg and t-Res. The results suggest a more rapid and pronounced response from ResArg than trans-Res on certain markers of vascular function.",
keywords = "Cardiovascular, Nitrate/nitrite, Platelets, Resveratrol, Vascular function",
author = "Dragana Djurica and Jingyan Ren and Holt, {Roberta R.} and Xianchao Feng and Carlson, {Charles R.} and Shindel, {Alan W} and Keen, {Carl L} and Hackman, {Robert M.}",
year = "2016",
month = "7",
day = "1",
doi = "10.1016/j.phanu.2016.05.002",
language = "English (US)",
volume = "4",
pages = "132--138",
journal = "PharmaNutrition",
issn = "2213-4344",
publisher = "Elsevier BV",
number = "3",

}

TY - JOUR

T1 - A single intake of a resveratrol-arginine conjugate improves microvascular function compared to trans-resveratrol in postmenopausal women

AU - Djurica, Dragana

AU - Ren, Jingyan

AU - Holt, Roberta R.

AU - Feng, Xianchao

AU - Carlson, Charles R.

AU - Shindel, Alan W

AU - Keen, Carl L

AU - Hackman, Robert M.

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Resveratrol supplementation has been reported to improve markers of vascular function, but poor bioavailability of the parent compound is thought to limits its use. In this study, we compared the effects of a resveratrol-arginine conjugate (ResArg) to trans-resveratrol (trans-Res), the standard form used in supplements, on measures of microvascular function 1 h and 2 h after intake. Postmenopausal women were assigned to consume 90 mg of resveratrol as either ResArg or t-Res, in a double-blind, randomized, crossover design, at least one week apart. Microvascular function was assessed by peripheral arterial tonometry, and calculated as the reactive hyperemia index (RHI) and the Framingham RHI (fRHI); at 1 h, platelet reactivity, plasma resveratrol and nitrate/nitrite levels were also measured. A significant increase in fRHI was observed 1 h after intake of ResArg compared to trans-Res. Significant reductions in platelet reactivity were noted 1 h after ResArg intake, but not for trans-Res. Plasma resveratrol levels were increased 30 and 60 min after the consumption of both ResArg and t-Res. The results suggest a more rapid and pronounced response from ResArg than trans-Res on certain markers of vascular function.

AB - Resveratrol supplementation has been reported to improve markers of vascular function, but poor bioavailability of the parent compound is thought to limits its use. In this study, we compared the effects of a resveratrol-arginine conjugate (ResArg) to trans-resveratrol (trans-Res), the standard form used in supplements, on measures of microvascular function 1 h and 2 h after intake. Postmenopausal women were assigned to consume 90 mg of resveratrol as either ResArg or t-Res, in a double-blind, randomized, crossover design, at least one week apart. Microvascular function was assessed by peripheral arterial tonometry, and calculated as the reactive hyperemia index (RHI) and the Framingham RHI (fRHI); at 1 h, platelet reactivity, plasma resveratrol and nitrate/nitrite levels were also measured. A significant increase in fRHI was observed 1 h after intake of ResArg compared to trans-Res. Significant reductions in platelet reactivity were noted 1 h after ResArg intake, but not for trans-Res. Plasma resveratrol levels were increased 30 and 60 min after the consumption of both ResArg and t-Res. The results suggest a more rapid and pronounced response from ResArg than trans-Res on certain markers of vascular function.

KW - Cardiovascular

KW - Nitrate/nitrite

KW - Platelets

KW - Resveratrol

KW - Vascular function

UR - http://www.scopus.com/inward/record.url?scp=84975512613&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84975512613&partnerID=8YFLogxK

U2 - 10.1016/j.phanu.2016.05.002

DO - 10.1016/j.phanu.2016.05.002

M3 - Article

VL - 4

SP - 132

EP - 138

JO - PharmaNutrition

JF - PharmaNutrition

SN - 2213-4344

IS - 3

ER -