A single-cell model to study changes in neuronal fractal dimension

Laura N Borodinsky, Mónica L. Fiszman

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Many methods have been developed to quantify neuronal morphology: measurement of neurite length, neurite number, etc. However, none of these approaches provides a comprehensive view of the complexity of neuronal morphology. In this work we have analyzed the evaluation of fractal dimension (D) as a tool to represent and quantify changes in complexity of the dendritic arbor, in in vitro cultures grown under Iow-density conditions. Neurons grown in isolation developed a bipolar morphology corresponding to a fractal dimension close to the unit. The analysis showed that neuronal complexity increased when cells were incubated with a depolarizing potassium concentration and there was a correlation with an increase in fractal dimension (D5 mM KCI = 1.08 ± 0.01, D25 mM KCI = 1.25 ± 0.01). We conclude that fractal dimension is a suitable parameter to quantify changes in neuronal morphological complexity.

Original languageEnglish (US)
Pages (from-to)341-345
Number of pages5
Issue number4
StatePublished - 2001
Externally publishedYes


  • Cerebellar granule cells
  • Fractal dimension
  • Neural activity
  • Neuronal complexity

ASJC Scopus subject areas

  • Molecular Biology


Dive into the research topics of 'A single-cell model to study changes in neuronal fractal dimension'. Together they form a unique fingerprint.

Cite this