A simulation study of a long axial field of view whole-body PET scanner using cylindrical and anthropomorphic phantoms

Jonathan K. Poon, Lawrence R. MacDonald, Simon R Cherry, Ramsey D Badawi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Scopus citations

Abstract

Clinical whole-body PET scanners mostly have an axial field of view (AFOV) ranging from 15-21 em in length, which limits sensitivity and prevents the acquisition of wholebody dynamic images. We present results from a simulation study for a fully 3D, 2 meter long AFOV whole body PET scanner where we use cylindrical and anthropomorphic phantoms to characterize the count-rate performance using noise equivalent counts (NEC) as the metric. For whole-body scanners with a conventional AFOV, the NEC is generally expected to increase when data from larger ring differences is accepted. However, the lines of response with large ring difference values may encounter a large amount of tissue and attenuation, which may limit the number of trues detected without a concomitant reduction in scatter and randoms, thus limiting NEC. When the activity level in the phantom increases, the dead-time and randoms also increase significantly, eventually reducing the NEC performance as well. In this simulation study, the NEC was computed as a function of maximum acquired ring difference and activity for each phantom to find optimal performance parameters for our proposed scanner. Our simulation results show our proposed scanner performs 25-50 times better than existing clinical scanners in terms of NEC performance. With significant gains in sensitivity, a long AFOV scanner can potentiaUy be used for whole body dynamic PET studies.

Original languageEnglish (US)
Title of host publicationIEEE Nuclear Science Symposium Conference Record
Pages4999-5006
Number of pages8
DOIs
StatePublished - 2008
Event2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008 - Dresden, Germany
Duration: Oct 19 2008Oct 25 2008

Other

Other2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008
CountryGermany
CityDresden
Period10/19/0810/25/08

Keywords

  • PET
  • PET 3D
  • Simulation

ASJC Scopus subject areas

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

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