A simple, fast, and accurate method of phylogenomic inference

Martin Wu, Jonathan A Eisen

Research output: Contribution to journalArticle

304 Citations (Scopus)

Abstract

The explosive growth of genomic data provides an opportunity to make increased use of protein markers for phylogenetic inference. We have developed an automated pipeline for phylogenomic analysis (AMPHORA) that overcomes the existing bottlenecks limiting large-scale protein phylogenetic inference. We demonstrated its high throughput capabilities and high quality results by constructing a genome tree of 578 bacterial species and by assigning phylotypes to 18,607 protein markers identified in metagenomic data collected from the Sargasso Sea.

Original languageEnglish (US)
Article numberR151
JournalGenome Biology
Volume9
Issue number10
DOIs
StatePublished - Oct 13 2008

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protein
phylogenetics
Metagenomics
Proteins
proteins
phylogeny
explosive
genomics
genome
methodology
Genome
Growth
method
marker
analysis
phylotype

ASJC Scopus subject areas

  • Genetics
  • Cell Biology
  • Ecology, Evolution, Behavior and Systematics

Cite this

A simple, fast, and accurate method of phylogenomic inference. / Wu, Martin; Eisen, Jonathan A.

In: Genome Biology, Vol. 9, No. 10, R151, 13.10.2008.

Research output: Contribution to journalArticle

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