A Simple 1-D Physical Model for the Crawling Nematode Sperm Cell

A. Mogilner, D. W. Verzi

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

We develop a one-dimensional physical model of the crawling movement of simple cells: The sperm of a nematode, Ascaris suum. The model is based on the assumptions that polymerization and bundling of the cytoskeletal filaments generate the force for extension at the front, and that energy stored in the gel formed from the filament bundles is subsequently used to produce the contraction that pulls the rear of the cell forward. The model combines the mechanics of protrusion and contraction with chemical control, and shows how their coupling generates stable rapid migration, so that the cell length and velocity regulate to constant values.

Original languageEnglish (US)
Pages (from-to)1169-1189
Number of pages21
JournalJournal of Statistical Physics
Volume110
Issue number3-6
DOIs
StatePublished - Mar 2003

Fingerprint

Physical Model
Filament
contraction
Contraction
filaments
Cell
cells
Polymerization
One-dimensional Model
bundles
Migration
Mechanics
Bundle
polymerization
gels
Energy
Model
energy

Keywords

  • Biophysical model
  • Brownian Ratchet
  • Cell movements
  • Entropic contraction

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Statistical and Nonlinear Physics
  • Mathematical Physics

Cite this

A Simple 1-D Physical Model for the Crawling Nematode Sperm Cell. / Mogilner, A.; Verzi, D. W.

In: Journal of Statistical Physics, Vol. 110, No. 3-6, 03.2003, p. 1169-1189.

Research output: Contribution to journalArticle

Mogilner, A. ; Verzi, D. W. / A Simple 1-D Physical Model for the Crawling Nematode Sperm Cell. In: Journal of Statistical Physics. 2003 ; Vol. 110, No. 3-6. pp. 1169-1189.
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