A sensitive ultrasonic imaging method for targeted contrast microbubble detection.

Hairong Zheng, Dustin E. Kruse, Douglas N. Stephens, Katherine W. Ferrara, Patrick Sutcliffe, Edward Gardner

Research output: Contribution to journalArticle

Abstract

We have recently developed a targeted imaging technique for selective and sensitive ultrasound molecular imaging by taking advantage of wideband transient high frequency acoustic emission from ultrasound contrast agents. The imaging modality makes use of a novel multi-frequency co-linear array (two outer 1.4 MHz and one center 5.3 MHz arrays) transducer integrated with the Siemens AntaresSystem. The imaging sequence includes a B-mode imaging pulse sequence in which a short pulse is transmitted with the outer low frequency arrays and received with the inner high frequency array (TLRH: transmit at low frequency and receive at high frequency), followed by a long radiation force pulse to induce immediate bubble adhesion using the center array, and a second B-mode imaging pulse sequence. The RF data obtained from the second B-mode pulse sequence are averaged and then subtracted from the first B-mode sequence. The imaging technique was tested in a targeted imaging phantom, where lipid-shelled biotin microbubbles flow within an avidin coated-cellulose. Results showed that tissue signals were suppressed up to 33 dB and a targeted bubble contrast-to-free bubble signal ratio of up to 23 dB was obtained from the composite sequence imaging.

Original languageEnglish (US)
Pages (from-to)5290-5293
Number of pages4
JournalConference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference
StatePublished - 2008
Externally publishedYes

Fingerprint

Imaging Phantoms
Ultrasonic imaging
Microbubbles
Molecular Imaging
Avidin
Biotin
Transducers
Acoustics
Cellulose
Contrast Media
Ultrasonography
Radiation
Lipids
Imaging techniques
Ultrasonics
Molecular imaging
Acoustic emissions
Adhesion
Tissue

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

Cite this

A sensitive ultrasonic imaging method for targeted contrast microbubble detection. / Zheng, Hairong; Kruse, Dustin E.; Stephens, Douglas N.; Ferrara, Katherine W.; Sutcliffe, Patrick; Gardner, Edward.

In: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 2008, p. 5290-5293.

Research output: Contribution to journalArticle

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