A semiautomated method for measuring brain infarct volume

Raymond A. Swanson, Matthew T. Morton, George Tsao-Wu, Robert A. Savalos, Charisse Davidson, Frank R Sharp

Research output: Contribution to journalArticlepeer-review

1415 Scopus citations


An accurate, reproducible method for determining the infarct volumes of gray matter structures is presented for use with presently available image analysis systems. Areas of stained sections with optical densities above that of a threshold value are automatically recognized and measured. This eliminates the potential error and bias inherent in manually delineating infarcted re-gions. Moreover, the volume of surviving normal gray matter is determined rather than that of the infarct. This approach minimizes the error that is introduced by edema, which distorts and enlarges the infarcted tissue and surrounding white matter.

Original languageEnglish (US)
Pages (from-to)290-293
Number of pages4
JournalJournal of Cerebral Blood Flow and Metabolism
Issue number2
StatePublished - 1990
Externally publishedYes


  • Brain
  • Infarction
  • Nissl stain
  • Succinate dehydrogenase

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)
  • Endocrinology, Diabetes and Metabolism


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