A search for Bordetella pertussis infection in university students

ChrisAnna Morgan Mink, James D. Cherry, Peter Christenson, Karen Lewis, Evelyn Pineda, Deborah Shlian, Jo Ann Dawson, Dean A Blumberg

Research output: Contribution to journalArticle

243 Citations (Scopus)

Abstract

University students with persistent cough of ≥6 days' duration were evaluated for evidence of infection with Bordetella pertussis. Of 130 students studied during a 30-month period, 34 (26%) were found to have evidence of recent infections with B. pertussis. Infection was identified by direct fluorescent antibody assay of a nasopharyngeal specimen in one student and serologically in 33 additional subjects. B. pertussis was not recovered on culture of nasopharyngeal specimens from any subjects. Students with B. pertussis infection were identified in seven of the eight 3-month periods in which students were enrolled during the 30-month investigation, suggesting an endemic rather than epidemic pattern of infection in this university population. Illnesses of students with pertussis were similar to the illnesses of students without pertussis. The findings in this study suggest that adult populations in which endemic illness occurs at a relatively constant rate may be the reservoirs for pertussis outbreaks in susceptible children. Immunization programs in the future will need to employ booster doses for adults if complete control of B. pertussis infection is our goal.

Original languageEnglish (US)
Pages (from-to)464-471
Number of pages8
JournalClinical Infectious Diseases
Volume14
Issue number2
StatePublished - Feb 1992

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Bordetella Infections
Bordetella pertussis
Students
Whooping Cough
Infection
Immunization Programs
Cough
Population
Disease Outbreaks
Antibodies

ASJC Scopus subject areas

  • Immunology

Cite this

Mink, C. M., Cherry, J. D., Christenson, P., Lewis, K., Pineda, E., Shlian, D., ... Blumberg, D. A. (1992). A search for Bordetella pertussis infection in university students. Clinical Infectious Diseases, 14(2), 464-471.

A search for Bordetella pertussis infection in university students. / Mink, ChrisAnna Morgan; Cherry, James D.; Christenson, Peter; Lewis, Karen; Pineda, Evelyn; Shlian, Deborah; Dawson, Jo Ann; Blumberg, Dean A.

In: Clinical Infectious Diseases, Vol. 14, No. 2, 02.1992, p. 464-471.

Research output: Contribution to journalArticle

Mink, CM, Cherry, JD, Christenson, P, Lewis, K, Pineda, E, Shlian, D, Dawson, JA & Blumberg, DA 1992, 'A search for Bordetella pertussis infection in university students', Clinical Infectious Diseases, vol. 14, no. 2, pp. 464-471.
Mink CM, Cherry JD, Christenson P, Lewis K, Pineda E, Shlian D et al. A search for Bordetella pertussis infection in university students. Clinical Infectious Diseases. 1992 Feb;14(2):464-471.
Mink, ChrisAnna Morgan ; Cherry, James D. ; Christenson, Peter ; Lewis, Karen ; Pineda, Evelyn ; Shlian, Deborah ; Dawson, Jo Ann ; Blumberg, Dean A. / A search for Bordetella pertussis infection in university students. In: Clinical Infectious Diseases. 1992 ; Vol. 14, No. 2. pp. 464-471.
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