A sandwich tubular scaffold derived from chitosan for blood vessel tissue engineering

Ling Zhang, Qiang Ao, Aijun Wang, Guangyuan Lu, Lijun Kong, Yandao Gong, Nanming Zhao, Xiufang Zhang

Research output: Contribution to journalArticlepeer-review

89 Scopus citations


Many materials have been investigated in blood vessel tissue engineering, such as PGA, PLGA, P4HB. However, chitosan is not mentioned in the arena. This study aimed to develop a chitosan-based tubular scaffold and examine its feasibility of being applied in this field. Briefly, a knitted chitosan tube was dipped into chitosan solution (2%, w/v) and dried, then its inner and outer surface was mantled with a layer of chitosan/gelatin (4:1, w/w) complex solution, and then freeze-dehydrated. In vitro characterization showed that the scaffold had a wall of 1.0 mm in thickness with a sandwich structure, and a porosity of 81.2%. The pore diameter was 50-150 μm and could be regulated by varying freezing conditions. The scaffold possessed proper swelling property, burst strength of almost 4000 mmHg, and high suture-retention strength. After degradation for 2 months, the scaffold could maintain enough mechanical strength with an average mass loss of 18.7%. Vascular smooth muscle cells could spread and grow very well on the scaffold. This study provided a novel method to fabricate chitosan and its complex into a tubular scaffold and demonstrated the feasibility of the scaffold employed in the field of blood vessel tissue engineering.

Original languageEnglish (US)
Pages (from-to)277-284
Number of pages8
JournalJournal of Biomedical Materials Research - Part A
Issue number2
StatePublished - May 2006
Externally publishedYes


  • Blood vessel tissue engineering
  • Chitosan
  • Knitting
  • Mechanical property
  • Tubular scaffold

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials


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