A Salmonella frameshift suppressor that acts at runs of a residues in the messenger RNA

Tadahiko Kohno; John R. Roth

doi:10.1016/0022-2836(78)90278-4

A Salmonella frameshift suppressor that acts at runs of a residues in the messenger RNA

Tadahiko Kohno, John R. Roth

Microbiology

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

A Salmonella mutation is described that suppresses + 1 frameshift mutations in runs of A residues in the messenger RNA. The suppressor mutation is dominant and maps very close to the nag locus at minute 15 of the Salmonella chromosome. A lysine transfer RNA is known to map very close to this position. Since the frameshift suppressor appears allelic to a nonsense suppressor (UA(A/G)), it seems likely that the suppressor will prove to affect lysine tRNA (AA(A/G)).

Original language	English (US)
Pages (from-to)	37-52
Number of pages	16
Journal	Journal of Molecular Biology
Volume	126
Issue number	1
DOIs	https://doi.org/10.1016/0022-2836(78)90278-4
State	Published - Nov 25 1978

ASJC Scopus subject areas

Virology

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10.1016/0022-2836(78)90278-4

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abstract = "A Salmonella mutation is described that suppresses + 1 frameshift mutations in runs of A residues in the messenger RNA. The suppressor mutation is dominant and maps very close to the nag locus at minute 15 of the Salmonella chromosome. A lysine transfer RNA is known to map very close to this position. Since the frameshift suppressor appears allelic to a nonsense suppressor (UA(A/G)), it seems likely that the suppressor will prove to affect lysine tRNA (AA(A/G)).",

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N2 - A Salmonella mutation is described that suppresses + 1 frameshift mutations in runs of A residues in the messenger RNA. The suppressor mutation is dominant and maps very close to the nag locus at minute 15 of the Salmonella chromosome. A lysine transfer RNA is known to map very close to this position. Since the frameshift suppressor appears allelic to a nonsense suppressor (UA(A/G)), it seems likely that the suppressor will prove to affect lysine tRNA (AA(A/G)).

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