A Salmonella mutation is described that suppresses + 1 frameshift mutations in runs of A residues in the messenger RNA. The suppressor mutation is dominant and maps very close to the nag locus at minute 15 of the Salmonella chromosome. A lysine transfer RNA is known to map very close to this position. Since the frameshift suppressor appears allelic to a nonsense suppressor (UA(A/G)), it seems likely that the suppressor will prove to affect lysine tRNA (AA(A/G)).
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