A role of MAP1B in reelin-dependent neuronal migration

Christian González-Billault; José A. Del Río; Jesús M. Ureña; Eva M. Jiménez-Mateos; María J. Barallobre; Marta Pascual; Lluís Pujadas; Sergi Simo Olivar; Anna La Torre Vila; Rosalina Gavin; Francisco Wandosell; Eduardo Soriano; Jesús Ávila

doi:10.1093/cercor/bhh213

A role of MAP1B in reelin-dependent neuronal migration

Christian González-Billault, José A. Del Río, Jesús M. Ureña, Eva M. Jiménez-Mateos, María J. Barallobre, Marta Pascual, Lluís Pujadas, Sergi Simo Olivar, Anna La Torre Vila, Rosalina Gavin, Francisco Wandosell, Eduardo Soriano, Jesús Ávila

Research output: Contribution to journal › Article

85 Scopus citations

Abstract

The signaling cascades governing neuronal migration are believed to link extracellular signals to cytoskeletal components. MAP1B is a neuron-specific microtubule-associated protein implicated in the control of the dynamic stability of microtubules and in the cross-talk between microtubules and actin filaments. Here we show that Reelin can induce mode I MAP1B phosphorylation, both in vivo and in vitro, through gsk3 and cdk5 activation. Additionally, mDab1 participates in the signaling cascade responsible for mode I MAP1B phosphorylation. Conversely, MAP1B-deficient mice display an abnormal structuring of the nervous system, especially in brain laminated areas, indicating a failure in neuronal migration. Therefore, we propose that Reelin can induce post-translational modifications on MAP1B that could correlate with its function in neuronal migration.

Original language	English (US)
Pages (from-to)	1134-1145
Number of pages	12
Journal	Cerebral Cortex
Volume	15
Issue number	8
DOIs	https://doi.org/10.1093/cercor/bhh213
State	Published - Aug 2005
Externally published	Yes

Keywords

Cyclin-dependent kinase 5
Glycogen synthase kinase 3
Microtubule-associated protein
Neuronal migration
Reelin

ASJC Scopus subject areas

Cognitive Neuroscience
Cellular and Molecular Neuroscience

Access to Document

10.1093/cercor/bhh213

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González-Billault, C., Del Río, J. A., Ureña, J. M., Jiménez-Mateos, E. M., Barallobre, M. J., Pascual, M., Pujadas, L., Simo Olivar, S., La Torre Vila, A., Gavin, R., Wandosell, F., Soriano, E., & Ávila, J. (2005). A role of MAP1B in reelin-dependent neuronal migration. Cerebral Cortex, 15(8), 1134-1145. https://doi.org/10.1093/cercor/bhh213

A role of MAP1B in reelin-dependent neuronal migration. / González-Billault, Christian; Del Río, José A.; Ureña, Jesús M.; Jiménez-Mateos, Eva M.; Barallobre, María J.; Pascual, Marta; Pujadas, Lluís; Simo Olivar, Sergi ; La Torre Vila, Anna; Gavin, Rosalina; Wandosell, Francisco; Soriano, Eduardo; Ávila, Jesús.

In: Cerebral Cortex, Vol. 15, No. 8, 08.2005, p. 1134-1145.

Research output: Contribution to journal › Article

González-Billault, Christian ; Del Río, José A. ; Ureña, Jesús M. ; Jiménez-Mateos, Eva M. ; Barallobre, María J. ; Pascual, Marta ; Pujadas, Lluís ; Simo Olivar, Sergi ; La Torre Vila, Anna ; Gavin, Rosalina ; Wandosell, Francisco ; Soriano, Eduardo ; Ávila, Jesús. / A role of MAP1B in reelin-dependent neuronal migration. In: Cerebral Cortex. 2005 ; Vol. 15, No. 8. pp. 1134-1145.

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