A role of MAP1B in reelin-dependent neuronal migration

Christian González-Billault, José A. Del Río, Jesús M. Ureña, Eva M. Jiménez-Mateos, María J. Barallobre, Marta Pascual, Lluís Pujadas, Sergi Simo Olivar, Anna La Torre Vila, Rosalina Gavin, Francisco Wandosell, Eduardo Soriano, Jesús Ávila

Research output: Contribution to journalArticlepeer-review

86 Scopus citations

Abstract

The signaling cascades governing neuronal migration are believed to link extracellular signals to cytoskeletal components. MAP1B is a neuron-specific microtubule-associated protein implicated in the control of the dynamic stability of microtubules and in the cross-talk between microtubules and actin filaments. Here we show that Reelin can induce mode I MAP1B phosphorylation, both in vivo and in vitro, through gsk3 and cdk5 activation. Additionally, mDab1 participates in the signaling cascade responsible for mode I MAP1B phosphorylation. Conversely, MAP1B-deficient mice display an abnormal structuring of the nervous system, especially in brain laminated areas, indicating a failure in neuronal migration. Therefore, we propose that Reelin can induce post-translational modifications on MAP1B that could correlate with its function in neuronal migration.

Original languageEnglish (US)
Pages (from-to)1134-1145
Number of pages12
JournalCerebral Cortex
Volume15
Issue number8
DOIs
StatePublished - Aug 2005
Externally publishedYes

Keywords

  • Cyclin-dependent kinase 5
  • Glycogen synthase kinase 3
  • Microtubule-associated protein
  • Neuronal migration
  • Reelin

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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