TY - JOUR
T1 - A role of MAP1B in reelin-dependent neuronal migration
AU - González-Billault, Christian
AU - Del Río, José A.
AU - Ureña, Jesús M.
AU - Jiménez-Mateos, Eva M.
AU - Barallobre, María J.
AU - Pascual, Marta
AU - Pujadas, Lluís
AU - Simo Olivar, Sergi
AU - La Torre Vila, Anna
AU - Gavin, Rosalina
AU - Wandosell, Francisco
AU - Soriano, Eduardo
AU - Ávila, Jesús
PY - 2005/8
Y1 - 2005/8
N2 - The signaling cascades governing neuronal migration are believed to link extracellular signals to cytoskeletal components. MAP1B is a neuron-specific microtubule-associated protein implicated in the control of the dynamic stability of microtubules and in the cross-talk between microtubules and actin filaments. Here we show that Reelin can induce mode I MAP1B phosphorylation, both in vivo and in vitro, through gsk3 and cdk5 activation. Additionally, mDab1 participates in the signaling cascade responsible for mode I MAP1B phosphorylation. Conversely, MAP1B-deficient mice display an abnormal structuring of the nervous system, especially in brain laminated areas, indicating a failure in neuronal migration. Therefore, we propose that Reelin can induce post-translational modifications on MAP1B that could correlate with its function in neuronal migration.
AB - The signaling cascades governing neuronal migration are believed to link extracellular signals to cytoskeletal components. MAP1B is a neuron-specific microtubule-associated protein implicated in the control of the dynamic stability of microtubules and in the cross-talk between microtubules and actin filaments. Here we show that Reelin can induce mode I MAP1B phosphorylation, both in vivo and in vitro, through gsk3 and cdk5 activation. Additionally, mDab1 participates in the signaling cascade responsible for mode I MAP1B phosphorylation. Conversely, MAP1B-deficient mice display an abnormal structuring of the nervous system, especially in brain laminated areas, indicating a failure in neuronal migration. Therefore, we propose that Reelin can induce post-translational modifications on MAP1B that could correlate with its function in neuronal migration.
KW - Cyclin-dependent kinase 5
KW - Glycogen synthase kinase 3
KW - Microtubule-associated protein
KW - Neuronal migration
KW - Reelin
UR - http://www.scopus.com/inward/record.url?scp=25444431830&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=25444431830&partnerID=8YFLogxK
U2 - 10.1093/cercor/bhh213
DO - 10.1093/cercor/bhh213
M3 - Article
C2 - 15590913
AN - SCOPUS:25444431830
VL - 15
SP - 1134
EP - 1145
JO - Cerebral Cortex
JF - Cerebral Cortex
SN - 1047-3211
IS - 8
ER -