A role of MAP1B in reelin-dependent neuronal migration

Christian González-Billault, José A. Del Río, Jesús M. Ureña, Eva M. Jiménez-Mateos, María J. Barallobre, Marta Pascual, Lluís Pujadas, Sergi Simo Olivar, Anna La Torre Vila, Rosalina Gavin, Francisco Wandosell, Eduardo Soriano, Jesús Ávila

Research output: Contribution to journalArticle

85 Scopus citations


The signaling cascades governing neuronal migration are believed to link extracellular signals to cytoskeletal components. MAP1B is a neuron-specific microtubule-associated protein implicated in the control of the dynamic stability of microtubules and in the cross-talk between microtubules and actin filaments. Here we show that Reelin can induce mode I MAP1B phosphorylation, both in vivo and in vitro, through gsk3 and cdk5 activation. Additionally, mDab1 participates in the signaling cascade responsible for mode I MAP1B phosphorylation. Conversely, MAP1B-deficient mice display an abnormal structuring of the nervous system, especially in brain laminated areas, indicating a failure in neuronal migration. Therefore, we propose that Reelin can induce post-translational modifications on MAP1B that could correlate with its function in neuronal migration.

Original languageEnglish (US)
Pages (from-to)1134-1145
Number of pages12
JournalCerebral Cortex
Issue number8
StatePublished - Aug 2005
Externally publishedYes


  • Cyclin-dependent kinase 5
  • Glycogen synthase kinase 3
  • Microtubule-associated protein
  • Neuronal migration
  • Reelin

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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  • Cite this

    González-Billault, C., Del Río, J. A., Ureña, J. M., Jiménez-Mateos, E. M., Barallobre, M. J., Pascual, M., Pujadas, L., Simo Olivar, S., La Torre Vila, A., Gavin, R., Wandosell, F., Soriano, E., & Ávila, J. (2005). A role of MAP1B in reelin-dependent neuronal migration. Cerebral Cortex, 15(8), 1134-1145. https://doi.org/10.1093/cercor/bhh213