A role for the EphA family in the topographic targeting of vomeronasal axons

B. Knöll, Konstantinos Zarbalis, W. Wurst, U. Drescher

Research output: Contribution to journalArticle

132 Scopus citations

Abstract

We have investigated the role of the Eph family of receptor tyrosine kinases and their ligands in the establishment of the vomeronasal projection in the mouse. Our data show intriguing differential expression patterns of ephrin-A5 on vomeronasal axons and of EphA6 in the accessory olfactory bulb (AOB), such that axons with high ligand concentration project onto regions of the AOB with high receptor concentration and vice versa. These data suggest a mechanism for development of this projection that is the opposite of the repellent interaction between Eph receptors and ligands observed in other systems. In support of this idea, when given the choice of whether to grow on lanes containing EphA-Fc/laminin or Fc/laminin protein (in the stripe assay), vomeronasal axons prefer to grow on EphA-Fc/laminin. Analysis of ephrin-A5 mutant mice revealed a disturbance of the topographic targeting of vomeronasal axons to the AOB. In summary, these data, which are derived from in vitro and in vivo experiments, indicate an important role of the EphA family in setting up the vomeronasal projection.

Original languageEnglish (US)
Pages (from-to)895-906
Number of pages12
JournalDevelopment
Volume128
Issue number6
StatePublished - 2001
Externally publishedYes

Keywords

  • Eph
  • Ephrin
  • Mouse
  • Topographic projection
  • Vomeronasal

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology

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