Abstract
The generation of nuclear signaling proteins by regulated intramembrane proteolysis (RIP) is a new paradigm of signal transduction. Mammalian proteins that are processed by RIP include SREBP-1, Notch-1, amyloid precursor protein (APP), and ErbB-4. Intramembranous γ-secretase cleavage of APP plays a central role in Alzheimer's disease by generating the amyloid β protein. An intriguing possibility is that the cognate C-terminal fragment generated by γ-secretase cleavage could also play a role through the regulation of nuclear signaling events. Thus, RIP may contribute to both brain development and degeneration and may provide unexpected diversity to the signaling repertoire of a cell.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 499-502 |
| Number of pages | 4 |
| Journal | Neuron |
| Volume | 34 |
| Issue number | 4 |
| DOIs | |
| State | Published - May 16 2002 |
| Externally published | Yes |
ASJC Scopus subject areas
- Neuroscience(all)
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Cite this
Ebinu, J., & Yankner, B. A. (2002). A RIP tide in neuronal signal transduction. Neuron, 34(4), 499-502. https://doi.org/10.1016/S0896-6273(02)00704-3