A RIP tide in neuronal signal transduction

Julius Ebinu, Bruce A. Yankner

Research output: Contribution to journalArticle

136 Citations (Scopus)

Abstract

The generation of nuclear signaling proteins by regulated intramembrane proteolysis (RIP) is a new paradigm of signal transduction. Mammalian proteins that are processed by RIP include SREBP-1, Notch-1, amyloid precursor protein (APP), and ErbB-4. Intramembranous γ-secretase cleavage of APP plays a central role in Alzheimer's disease by generating the amyloid β protein. An intriguing possibility is that the cognate C-terminal fragment generated by γ-secretase cleavage could also play a role through the regulation of nuclear signaling events. Thus, RIP may contribute to both brain development and degeneration and may provide unexpected diversity to the signaling repertoire of a cell.

Original languageEnglish (US)
Pages (from-to)499-502
Number of pages4
JournalNeuron
Volume34
Issue number4
DOIs
StatePublished - May 16 2002
Externally publishedYes

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Proteolysis
Signal Transduction
Amyloid Precursor Protein Secretases
Amyloidogenic Proteins
Amyloid beta-Protein Precursor
Nuclear Proteins
Alzheimer Disease
Brain
Proteins

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

A RIP tide in neuronal signal transduction. / Ebinu, Julius; Yankner, Bruce A.

In: Neuron, Vol. 34, No. 4, 16.05.2002, p. 499-502.

Research output: Contribution to journalArticle

Ebinu, Julius ; Yankner, Bruce A. / A RIP tide in neuronal signal transduction. In: Neuron. 2002 ; Vol. 34, No. 4. pp. 499-502.
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