Abstract
The generation of nuclear signaling proteins by regulated intramembrane proteolysis (RIP) is a new paradigm of signal transduction. Mammalian proteins that are processed by RIP include SREBP-1, Notch-1, amyloid precursor protein (APP), and ErbB-4. Intramembranous γ-secretase cleavage of APP plays a central role in Alzheimer's disease by generating the amyloid β protein. An intriguing possibility is that the cognate C-terminal fragment generated by γ-secretase cleavage could also play a role through the regulation of nuclear signaling events. Thus, RIP may contribute to both brain development and degeneration and may provide unexpected diversity to the signaling repertoire of a cell.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 499-502 |
| Number of pages | 4 |
| Journal | Neuron |
| Volume | 34 |
| Issue number | 4 |
| DOIs | |
| State | Published - May 16 2002 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Neuroscience(all)
Cite this
A RIP tide in neuronal signal transduction. / Ebinu, Julius; Yankner, Bruce A.
In: Neuron, Vol. 34, No. 4, 16.05.2002, p. 499-502.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A RIP tide in neuronal signal transduction
AU - Ebinu, Julius
AU - Yankner, Bruce A.
PY - 2002/5/16
Y1 - 2002/5/16
N2 - The generation of nuclear signaling proteins by regulated intramembrane proteolysis (RIP) is a new paradigm of signal transduction. Mammalian proteins that are processed by RIP include SREBP-1, Notch-1, amyloid precursor protein (APP), and ErbB-4. Intramembranous γ-secretase cleavage of APP plays a central role in Alzheimer's disease by generating the amyloid β protein. An intriguing possibility is that the cognate C-terminal fragment generated by γ-secretase cleavage could also play a role through the regulation of nuclear signaling events. Thus, RIP may contribute to both brain development and degeneration and may provide unexpected diversity to the signaling repertoire of a cell.
AB - The generation of nuclear signaling proteins by regulated intramembrane proteolysis (RIP) is a new paradigm of signal transduction. Mammalian proteins that are processed by RIP include SREBP-1, Notch-1, amyloid precursor protein (APP), and ErbB-4. Intramembranous γ-secretase cleavage of APP plays a central role in Alzheimer's disease by generating the amyloid β protein. An intriguing possibility is that the cognate C-terminal fragment generated by γ-secretase cleavage could also play a role through the regulation of nuclear signaling events. Thus, RIP may contribute to both brain development and degeneration and may provide unexpected diversity to the signaling repertoire of a cell.
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UR - http://www.scopus.com/inward/citedby.url?scp=0037118248&partnerID=8YFLogxK
U2 - 10.1016/S0896-6273(02)00704-3
DO - 10.1016/S0896-6273(02)00704-3
M3 - Article
C2 - 12062033
AN - SCOPUS:0037118248
VL - 34
SP - 499
EP - 502
JO - Neuron
JF - Neuron
SN - 0896-6273
IS - 4
ER -