A rhesus monkey model of respiratory syncytial virus infection

K. McArthur-Vaughan, Laurel J Gershwin

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract disease in infants and young children worldwide. To date, there is no single animal model that adequately reproduces all human disease states. Here, we have developed a model of experimental infection with human RSV in infant Rhesus macaques. Infected animals demonstrated mild clinical disease including increased respiratory rates, fever and adventitious lung sounds. While more severe disease was not observed, preliminary virological and histopathological findings are promising. It is anticipated that with further optimization, this model will provide a useful system with which to study disease due to RSV infection and evaluate candidate vaccines.

Original languageEnglish (US)
Pages (from-to)61-73
Number of pages13
JournalJournal of Medical Primatology
Volume31
Issue number2
DOIs
StatePublished - 2002

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Keywords

  • Infants
  • Respiratory
  • Rhesus macaque
  • Viral

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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