Abstract
Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract disease in infants and young children worldwide. To date, there is no single animal model that adequately reproduces all human disease states. Here, we have developed a model of experimental infection with human RSV in infant Rhesus macaques. Infected animals demonstrated mild clinical disease including increased respiratory rates, fever and adventitious lung sounds. While more severe disease was not observed, preliminary virological and histopathological findings are promising. It is anticipated that with further optimization, this model will provide a useful system with which to study disease due to RSV infection and evaluate candidate vaccines.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 61-73 |
| Number of pages | 13 |
| Journal | Journal of Medical Primatology |
| Volume | 31 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2002 |
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Keywords
- Infants
- Respiratory
- Rhesus macaque
- Viral
ASJC Scopus subject areas
- Animal Science and Zoology
- veterinary(all)
Cite this
A rhesus monkey model of respiratory syncytial virus infection. / McArthur-Vaughan, K.; Gershwin, Laurel J.
In: Journal of Medical Primatology, Vol. 31, No. 2, 2002, p. 61-73.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A rhesus monkey model of respiratory syncytial virus infection
AU - McArthur-Vaughan, K.
AU - Gershwin, Laurel J
PY - 2002
Y1 - 2002
N2 - Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract disease in infants and young children worldwide. To date, there is no single animal model that adequately reproduces all human disease states. Here, we have developed a model of experimental infection with human RSV in infant Rhesus macaques. Infected animals demonstrated mild clinical disease including increased respiratory rates, fever and adventitious lung sounds. While more severe disease was not observed, preliminary virological and histopathological findings are promising. It is anticipated that with further optimization, this model will provide a useful system with which to study disease due to RSV infection and evaluate candidate vaccines.
AB - Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract disease in infants and young children worldwide. To date, there is no single animal model that adequately reproduces all human disease states. Here, we have developed a model of experimental infection with human RSV in infant Rhesus macaques. Infected animals demonstrated mild clinical disease including increased respiratory rates, fever and adventitious lung sounds. While more severe disease was not observed, preliminary virological and histopathological findings are promising. It is anticipated that with further optimization, this model will provide a useful system with which to study disease due to RSV infection and evaluate candidate vaccines.
KW - Infants
KW - Respiratory
KW - Rhesus macaque
KW - Viral
UR - http://www.scopus.com/inward/record.url?scp=0036094103&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036094103&partnerID=8YFLogxK
U2 - 10.1034/j.1600-0684.2002.01006.x
DO - 10.1034/j.1600-0684.2002.01006.x
M3 - Article
C2 - 12110049
AN - SCOPUS:0036094103
VL - 31
SP - 61
EP - 73
JO - Journal of Medical Primatology
JF - Journal of Medical Primatology
SN - 0047-2565
IS - 2
ER -