A rhesus monkey model of respiratory syncytial virus infection

K. McArthur-Vaughan, Laurel J Gershwin

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract disease in infants and young children worldwide. To date, there is no single animal model that adequately reproduces all human disease states. Here, we have developed a model of experimental infection with human RSV in infant Rhesus macaques. Infected animals demonstrated mild clinical disease including increased respiratory rates, fever and adventitious lung sounds. While more severe disease was not observed, preliminary virological and histopathological findings are promising. It is anticipated that with further optimization, this model will provide a useful system with which to study disease due to RSV infection and evaluate candidate vaccines.

Original languageEnglish (US)
Pages (from-to)61-73
Number of pages13
JournalJournal of Medical Primatology
Volume31
Issue number2
DOIs
StatePublished - 2002

Fingerprint

Respiratory Syncytial Virus Infections
Macaca mulatta
Human respiratory syncytial virus
viruses
respiratory rate
human diseases
infection
respiratory tract diseases
fever
animal models
lungs
vaccines
Respiratory Tract Diseases
Respiratory Syncytial Viruses
Respiratory Sounds
Respiratory Rate
animals
Fever
Theoretical Models
Vaccines

Keywords

  • Infants
  • Respiratory
  • Rhesus macaque
  • Viral

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

A rhesus monkey model of respiratory syncytial virus infection. / McArthur-Vaughan, K.; Gershwin, Laurel J.

In: Journal of Medical Primatology, Vol. 31, No. 2, 2002, p. 61-73.

Research output: Contribution to journalArticle

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