Abstract
Our understanding of biliary epithelial cells (BEC) in physiobiology and immunology has steadily expanded. BEC transports IgA as well as IgM into bile, synthesizes and secretes various chemokines, cytokines, and expresses adhesion molecules involved in cell interaction and signal transduction. These then suggest a myriad of potential roles for BEC in defense from invading microorganisms as well as the pathogenesis of diverse immunologically driven diseases such as primary biliary cirrhosis (PBC), graft-versus-host disease, and primary sclerosing cholangitis (PSC). Despite the progress, there still remain many areas of BEC biology that require further investigation. Most importantly, it remains to be clarified that the extent to which the immunologic activities observed in BEC represent a BEC response to tissue injury or whether BEC themselves are the active participants in the pathogenesis of various cholestatic immunological diseases, including PBC and PSC.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 205-213 |
| Number of pages | 9 |
| Journal | Clinical and Developmental Immunology |
| Volume | 11 |
| Issue number | 3-4 |
| DOIs | |
| State | Published - Sep 2004 |
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Keywords
- Biliary epithelial cells
- IgA
- Primary biliary cirrhosis
- Primary sclerosing cholangitis
ASJC Scopus subject areas
- Immunology
- Cell Biology
- Developmental Biology
Cite this
A review of the physiological and immunological functions of biliary epithelial cells : Targets for primary biliary cirrhosis, primary sclerosing cholangitis and drug-induced ductopenias. / Wu, Chih Te; Davis, Paul A.; Luketic, Velimir A.; Gershwin, M. Eric.
In: Clinical and Developmental Immunology, Vol. 11, No. 3-4, 09.2004, p. 205-213.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A review of the physiological and immunological functions of biliary epithelial cells
T2 - Targets for primary biliary cirrhosis, primary sclerosing cholangitis and drug-induced ductopenias
AU - Wu, Chih Te
AU - Davis, Paul A.
AU - Luketic, Velimir A.
AU - Gershwin, M. Eric
PY - 2004/9
Y1 - 2004/9
N2 - Our understanding of biliary epithelial cells (BEC) in physiobiology and immunology has steadily expanded. BEC transports IgA as well as IgM into bile, synthesizes and secretes various chemokines, cytokines, and expresses adhesion molecules involved in cell interaction and signal transduction. These then suggest a myriad of potential roles for BEC in defense from invading microorganisms as well as the pathogenesis of diverse immunologically driven diseases such as primary biliary cirrhosis (PBC), graft-versus-host disease, and primary sclerosing cholangitis (PSC). Despite the progress, there still remain many areas of BEC biology that require further investigation. Most importantly, it remains to be clarified that the extent to which the immunologic activities observed in BEC represent a BEC response to tissue injury or whether BEC themselves are the active participants in the pathogenesis of various cholestatic immunological diseases, including PBC and PSC.
AB - Our understanding of biliary epithelial cells (BEC) in physiobiology and immunology has steadily expanded. BEC transports IgA as well as IgM into bile, synthesizes and secretes various chemokines, cytokines, and expresses adhesion molecules involved in cell interaction and signal transduction. These then suggest a myriad of potential roles for BEC in defense from invading microorganisms as well as the pathogenesis of diverse immunologically driven diseases such as primary biliary cirrhosis (PBC), graft-versus-host disease, and primary sclerosing cholangitis (PSC). Despite the progress, there still remain many areas of BEC biology that require further investigation. Most importantly, it remains to be clarified that the extent to which the immunologic activities observed in BEC represent a BEC response to tissue injury or whether BEC themselves are the active participants in the pathogenesis of various cholestatic immunological diseases, including PBC and PSC.
KW - Biliary epithelial cells
KW - IgA
KW - Primary biliary cirrhosis
KW - Primary sclerosing cholangitis
UR - http://www.scopus.com/inward/record.url?scp=7044232035&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=7044232035&partnerID=8YFLogxK
U2 - 10.1080/17402520400004177
DO - 10.1080/17402520400004177
M3 - Article
C2 - 15559365
AN - SCOPUS:7044232035
VL - 11
SP - 205
EP - 213
JO - Journal of Immunology Research
JF - Journal of Immunology Research
SN - 2314-8861
IS - 3-4
ER -