A review of the physiological and immunological functions of biliary epithelial cells: Targets for primary biliary cirrhosis, primary sclerosing cholangitis and drug-induced ductopenias

Chih Te Wu, Paul A. Davis, Velimir A. Luketic, M. Eric Gershwin

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Our understanding of biliary epithelial cells (BEC) in physiobiology and immunology has steadily expanded. BEC transports IgA as well as IgM into bile, synthesizes and secretes various chemokines, cytokines, and expresses adhesion molecules involved in cell interaction and signal transduction. These then suggest a myriad of potential roles for BEC in defense from invading microorganisms as well as the pathogenesis of diverse immunologically driven diseases such as primary biliary cirrhosis (PBC), graft-versus-host disease, and primary sclerosing cholangitis (PSC). Despite the progress, there still remain many areas of BEC biology that require further investigation. Most importantly, it remains to be clarified that the extent to which the immunologic activities observed in BEC represent a BEC response to tissue injury or whether BEC themselves are the active participants in the pathogenesis of various cholestatic immunological diseases, including PBC and PSC.

Original languageEnglish (US)
Pages (from-to)205-213
Number of pages9
JournalClinical and Developmental Immunology
Volume11
Issue number3-4
DOIs
StatePublished - Sep 2004

Fingerprint

Sclerosing Solutions
Sclerosing Cholangitis
Biliary Liver Cirrhosis
Epithelial Cells
Immune System Diseases
Graft vs Host Disease
Allergy and Immunology
Chemokines
Bile
Cell Communication
Immunoglobulin A
Immunoglobulin M
Cell Biology
Signal Transduction
Cytokines
Wounds and Injuries

Keywords

  • Biliary epithelial cells
  • IgA
  • Primary biliary cirrhosis
  • Primary sclerosing cholangitis

ASJC Scopus subject areas

  • Immunology
  • Cell Biology
  • Developmental Biology

Cite this

@article{9be646b956244fb58647ad9643f6934c,
title = "A review of the physiological and immunological functions of biliary epithelial cells: Targets for primary biliary cirrhosis, primary sclerosing cholangitis and drug-induced ductopenias",
abstract = "Our understanding of biliary epithelial cells (BEC) in physiobiology and immunology has steadily expanded. BEC transports IgA as well as IgM into bile, synthesizes and secretes various chemokines, cytokines, and expresses adhesion molecules involved in cell interaction and signal transduction. These then suggest a myriad of potential roles for BEC in defense from invading microorganisms as well as the pathogenesis of diverse immunologically driven diseases such as primary biliary cirrhosis (PBC), graft-versus-host disease, and primary sclerosing cholangitis (PSC). Despite the progress, there still remain many areas of BEC biology that require further investigation. Most importantly, it remains to be clarified that the extent to which the immunologic activities observed in BEC represent a BEC response to tissue injury or whether BEC themselves are the active participants in the pathogenesis of various cholestatic immunological diseases, including PBC and PSC.",
keywords = "Biliary epithelial cells, IgA, Primary biliary cirrhosis, Primary sclerosing cholangitis",
author = "Wu, {Chih Te} and Davis, {Paul A.} and Luketic, {Velimir A.} and Gershwin, {M. Eric}",
year = "2004",
month = "9",
doi = "10.1080/17402520400004177",
language = "English (US)",
volume = "11",
pages = "205--213",
journal = "Journal of Immunology Research",
issn = "2314-8861",
publisher = "Hindawi Publishing Corporation",
number = "3-4",

}

TY - JOUR

T1 - A review of the physiological and immunological functions of biliary epithelial cells

T2 - Targets for primary biliary cirrhosis, primary sclerosing cholangitis and drug-induced ductopenias

AU - Wu, Chih Te

AU - Davis, Paul A.

AU - Luketic, Velimir A.

AU - Gershwin, M. Eric

PY - 2004/9

Y1 - 2004/9

N2 - Our understanding of biliary epithelial cells (BEC) in physiobiology and immunology has steadily expanded. BEC transports IgA as well as IgM into bile, synthesizes and secretes various chemokines, cytokines, and expresses adhesion molecules involved in cell interaction and signal transduction. These then suggest a myriad of potential roles for BEC in defense from invading microorganisms as well as the pathogenesis of diverse immunologically driven diseases such as primary biliary cirrhosis (PBC), graft-versus-host disease, and primary sclerosing cholangitis (PSC). Despite the progress, there still remain many areas of BEC biology that require further investigation. Most importantly, it remains to be clarified that the extent to which the immunologic activities observed in BEC represent a BEC response to tissue injury or whether BEC themselves are the active participants in the pathogenesis of various cholestatic immunological diseases, including PBC and PSC.

AB - Our understanding of biliary epithelial cells (BEC) in physiobiology and immunology has steadily expanded. BEC transports IgA as well as IgM into bile, synthesizes and secretes various chemokines, cytokines, and expresses adhesion molecules involved in cell interaction and signal transduction. These then suggest a myriad of potential roles for BEC in defense from invading microorganisms as well as the pathogenesis of diverse immunologically driven diseases such as primary biliary cirrhosis (PBC), graft-versus-host disease, and primary sclerosing cholangitis (PSC). Despite the progress, there still remain many areas of BEC biology that require further investigation. Most importantly, it remains to be clarified that the extent to which the immunologic activities observed in BEC represent a BEC response to tissue injury or whether BEC themselves are the active participants in the pathogenesis of various cholestatic immunological diseases, including PBC and PSC.

KW - Biliary epithelial cells

KW - IgA

KW - Primary biliary cirrhosis

KW - Primary sclerosing cholangitis

UR - http://www.scopus.com/inward/record.url?scp=7044232035&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=7044232035&partnerID=8YFLogxK

U2 - 10.1080/17402520400004177

DO - 10.1080/17402520400004177

M3 - Article

C2 - 15559365

AN - SCOPUS:7044232035

VL - 11

SP - 205

EP - 213

JO - Journal of Immunology Research

JF - Journal of Immunology Research

SN - 2314-8861

IS - 3-4

ER -