A review of experimental evidence linking neurotoxic organophosphorus compounds and inflammation

Christopher N. Banks, Pamela J Lein

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

Organophosphorus (OP) nerve agents and pesticides inhibit acetylcholinesterase (AChE), and this is thought to be a primary mechanism mediating the neurotoxicity of these compounds. However, a number of observations suggest that mechanisms other than or in addition to AChE inhibition contribute to OP neurotoxicity. There is significant experimental evidence that acute OP intoxication elicits a robust inflammatory response, and emerging evidence suggests that chronic repeated low-level OP exposure also upregulates inflammatory mediators. A critical question that is just beginning to be addressed experimentally is the pathophysiologic relevance of inflammation in either acute or chronic OP intoxication. The goal of this article is to provide a brief review of the current status of our knowledge linking inflammation to OP intoxication, and to discuss the implications of these findings in the context of therapeutic and diagnostic approaches to OP neurotoxicity.

Original languageEnglish (US)
Pages (from-to)575-584
Number of pages10
JournalNeuroToxicology
Volume33
Issue number3
DOIs
StatePublished - Jun 2012

Fingerprint

Organophosphorus Compounds
Acetylcholinesterase
Inflammation
Pesticides
Up-Regulation
Therapeutics
Nerve Agents

Keywords

  • Acute toxicity
  • Biomarkers
  • Chronic toxicity
  • Cytokines
  • Microglia
  • Neuroinflammation
  • Neuroprotection
  • Neurotoxicity
  • Occupational exposure
  • Organophosphorus pesticides
  • Reactive astrocytes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Toxicology

Cite this

A review of experimental evidence linking neurotoxic organophosphorus compounds and inflammation. / Banks, Christopher N.; Lein, Pamela J.

In: NeuroToxicology, Vol. 33, No. 3, 06.2012, p. 575-584.

Research output: Contribution to journalArticle

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