A review of drugs in development for the personalized treatment of head and neck squamous cell carcinoma

Andrew C. Birkeland; Paul L. Swiecicki; J. Chad Brenner; Andrew G. Shuman

doi:10.1080/23808993.2016.1208050

A review of drugs in development for the personalized treatment of head and neck squamous cell carcinoma

Andrew C. Birkeland, Paul L. Swiecicki, J. Chad Brenner, Andrew G. Shuman

Research output: Contribution to journal › Review article

1 Scopus citations

Abstract

Introduction: Head and neck squamous cell carcinoma remains a highly morbid and fatal disease, with poor survival rates among patients with advanced and recurrent disease. Recent advances in next generation sequencing, targeted therapeutics, and precision medicine trials are expanding treatment options for head and neck cancers; thus greater awareness of this rapidly evolving field is important. Areas covered: Recent next-generation sequencing studies in head and neck squamous cell carcinoma, targeted therapy clinical trials involving head and neck squamous cell carcinoma. Expert commentary: This review discusses the current state of head and neck cancer treatment, and considerations and implications for the incorporation of personalized medicine and targeted therapy for head and neck cancers in a dynamic clinical landscape.

Original language	English (US)
Pages (from-to)	379-385
Number of pages	7
Journal	Expert Review of Precision Medicine and Drug Development
Volume	1
Issue number	4
DOIs	https://doi.org/10.1080/23808993.2016.1208050
State	Published - Jul 3 2016
Externally published	Yes

Keywords

Head and neck cancer
HNSCC
personalized medicine
precision medicine
targeted therapy

ASJC Scopus subject areas

Molecular Medicine
Genetics
Pharmacology
Drug Discovery

Access to Document

10.1080/23808993.2016.1208050

Fingerprint Dive into the research topics of 'A review of drugs in development for the personalized treatment of head and neck squamous cell carcinoma'. Together they form a unique fingerprint.

Cite this

Birkeland, A. C., Swiecicki, P. L., Brenner, J. C., & Shuman, A. G. (2016). A review of drugs in development for the personalized treatment of head and neck squamous cell carcinoma. Expert Review of Precision Medicine and Drug Development, 1(4), 379-385. https://doi.org/10.1080/23808993.2016.1208050

@article{cc5ce77c052a4920b04951a702f863b0,

title = "A review of drugs in development for the personalized treatment of head and neck squamous cell carcinoma",

abstract = "Introduction: Head and neck squamous cell carcinoma remains a highly morbid and fatal disease, with poor survival rates among patients with advanced and recurrent disease. Recent advances in next generation sequencing, targeted therapeutics, and precision medicine trials are expanding treatment options for head and neck cancers; thus greater awareness of this rapidly evolving field is important. Areas covered: Recent next-generation sequencing studies in head and neck squamous cell carcinoma, targeted therapy clinical trials involving head and neck squamous cell carcinoma. Expert commentary: This review discusses the current state of head and neck cancer treatment, and considerations and implications for the incorporation of personalized medicine and targeted therapy for head and neck cancers in a dynamic clinical landscape.",

keywords = "Head and neck cancer, HNSCC, personalized medicine, precision medicine, targeted therapy",

author = "Birkeland, {Andrew C.} and Swiecicki, {Paul L.} and Brenner, {J. Chad} and Shuman, {Andrew G.}",

year = "2016",

month = jul,

day = "3",

doi = "10.1080/23808993.2016.1208050",

language = "English (US)",

volume = "1",

pages = "379--385",

journal = "Expert Review of Precision Medicine and Drug Development",

issn = "2380-8993",

publisher = "Taylor and Francis Ltd.",

number = "4",

}

TY - JOUR

T1 - A review of drugs in development for the personalized treatment of head and neck squamous cell carcinoma

AU - Birkeland, Andrew C.

AU - Swiecicki, Paul L.

AU - Brenner, J. Chad

AU - Shuman, Andrew G.

PY - 2016/7/3

Y1 - 2016/7/3

N2 - Introduction: Head and neck squamous cell carcinoma remains a highly morbid and fatal disease, with poor survival rates among patients with advanced and recurrent disease. Recent advances in next generation sequencing, targeted therapeutics, and precision medicine trials are expanding treatment options for head and neck cancers; thus greater awareness of this rapidly evolving field is important. Areas covered: Recent next-generation sequencing studies in head and neck squamous cell carcinoma, targeted therapy clinical trials involving head and neck squamous cell carcinoma. Expert commentary: This review discusses the current state of head and neck cancer treatment, and considerations and implications for the incorporation of personalized medicine and targeted therapy for head and neck cancers in a dynamic clinical landscape.

AB - Introduction: Head and neck squamous cell carcinoma remains a highly morbid and fatal disease, with poor survival rates among patients with advanced and recurrent disease. Recent advances in next generation sequencing, targeted therapeutics, and precision medicine trials are expanding treatment options for head and neck cancers; thus greater awareness of this rapidly evolving field is important. Areas covered: Recent next-generation sequencing studies in head and neck squamous cell carcinoma, targeted therapy clinical trials involving head and neck squamous cell carcinoma. Expert commentary: This review discusses the current state of head and neck cancer treatment, and considerations and implications for the incorporation of personalized medicine and targeted therapy for head and neck cancers in a dynamic clinical landscape.

KW - Head and neck cancer

KW - HNSCC

KW - personalized medicine

KW - precision medicine

KW - targeted therapy

UR - http://www.scopus.com/inward/record.url?scp=85047450658&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85047450658&partnerID=8YFLogxK

U2 - 10.1080/23808993.2016.1208050

DO - 10.1080/23808993.2016.1208050

M3 - Review article

AN - SCOPUS:85047450658

VL - 1

SP - 379

EP - 385

JO - Expert Review of Precision Medicine and Drug Development

JF - Expert Review of Precision Medicine and Drug Development

SN - 2380-8993

IS - 4

ER -