A Review of Current Standards and the Evolution of Histopathology Nomenclature for Laboratory Animals

Susan A. Elmore, Robert Cardiff, Mark F. Cesta, Georgios V. Gkoutos, Robert Hoehndorf, Charlotte M. Keenan, Colin McKerlie, Paul N. Schofield, John P. Sundberg, Jerrold M. Ward

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

The need for international collaboration in rodent pathology has evolved since the 1970s and was initially driven by the new field of toxicologic pathology. First initiated by the World Health Organization's International Agency for Research on Cancer for rodents, it has evolved to include pathology of the major species (rats, mice, guinea pigs, nonhuman primates, pigs, dogs, fish, rabbits) used in medical research, safety assessment, and mouse pathology. The collaborative effort today is driven by the needs of the regulatory agencies in multiple countries, and by needs of research involving genetically engineered animals, for "basic" research and for more translational preclinical models of human disease. These efforts led to the establishment of an international rodent pathology nomenclature program. Since that time, multiple collaborations for standardization of laboratory animal pathology nomenclature and diagnostic criteria have been developed, and just a few are described herein. Recently, approaches to a nomenclature that is amenable to sophisticated computation have been made available and implemented for large-scale programs in functional genomics and aging. Most terminologies continue to evolve as the science of human and veterinary pathology continues to develop, but standardization and successful implementation remain critical for scientific communication now as ever in the history of veterinary nosology.

Original languageEnglish (US)
Pages (from-to)29-39
Number of pages11
JournalILAR Journal
Volume59
Issue number1
DOIs
StatePublished - Jan 1 2018

Fingerprint

Laboratory Animals
Pathology
Terminology
histopathology
laboratory animals
Animals
rodents
standardization
animal pathology
Siganus
Rodentia
safety assessment
biomedical research
mice
World Health Organization
terminology
human diseases
guinea pigs
animal communication
Primates

Keywords

  • International Agency for Research on Cancer
  • International Harmonization of Nomenclature and Diagnostic Criteria
  • International Mouse Phenotyping Consortium
  • mouse pathology ontology
  • National Cancer Institute Mouse Models of Human Cancer Consortium
  • National Toxicology Program Nonneoplastic Lesion Atlas
  • nomenclature
  • standard for exchange of nonclinical data

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Elmore, S. A., Cardiff, R., Cesta, M. F., Gkoutos, G. V., Hoehndorf, R., Keenan, C. M., ... Ward, J. M. (2018). A Review of Current Standards and the Evolution of Histopathology Nomenclature for Laboratory Animals. ILAR Journal, 59(1), 29-39. https://doi.org/10.1093/ilar/ily005

A Review of Current Standards and the Evolution of Histopathology Nomenclature for Laboratory Animals. / Elmore, Susan A.; Cardiff, Robert; Cesta, Mark F.; Gkoutos, Georgios V.; Hoehndorf, Robert; Keenan, Charlotte M.; McKerlie, Colin; Schofield, Paul N.; Sundberg, John P.; Ward, Jerrold M.

In: ILAR Journal, Vol. 59, No. 1, 01.01.2018, p. 29-39.

Research output: Contribution to journalReview article

Elmore, SA, Cardiff, R, Cesta, MF, Gkoutos, GV, Hoehndorf, R, Keenan, CM, McKerlie, C, Schofield, PN, Sundberg, JP & Ward, JM 2018, 'A Review of Current Standards and the Evolution of Histopathology Nomenclature for Laboratory Animals', ILAR Journal, vol. 59, no. 1, pp. 29-39. https://doi.org/10.1093/ilar/ily005
Elmore, Susan A. ; Cardiff, Robert ; Cesta, Mark F. ; Gkoutos, Georgios V. ; Hoehndorf, Robert ; Keenan, Charlotte M. ; McKerlie, Colin ; Schofield, Paul N. ; Sundberg, John P. ; Ward, Jerrold M. / A Review of Current Standards and the Evolution of Histopathology Nomenclature for Laboratory Animals. In: ILAR Journal. 2018 ; Vol. 59, No. 1. pp. 29-39.
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