A review of coronavirus infection in the central nervous system of cats and mice

Janet E Foley, Christian Leutenegger

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Feline infectious peritonitis (FIP) is a common cause of death in cats. Management of this disease has been hampered by difficulties identifying the infection and determining the immunological status of affected cats and by high variability in the clinical, pathological, and immunological characteristics of affected cats. Neurological FIP, which is much more homogeneous than systemic effusive or noneffusive FIP, appears to be a good model for establishing the basic features of FIP immunopathogenesis. Very little information is available about the immunopathogenesis of neurologic FIP, and it is reasonable to use research from the well-characterized mouse hepatitis virus (MHV) immune-mediated encephalitis system, as a template for FIP investigation, and to contrast findings from the MHV model with those of FIP. It is expected that the immunopathogenic mechanisms will have important similarities. Such comparative research may lead to better understanding of FIP immunopathogenesis and rational prospects for management of this frustrating disease.

Original languageEnglish (US)
Pages (from-to)438-444
Number of pages7
JournalJournal of Veterinary Internal Medicine
Issue number5
StatePublished - 2001


  • Cats
  • Feline infectious peritonitis
  • Mouse hepatitis virus
  • Neurological disease

ASJC Scopus subject areas

  • veterinary(all)


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