Abstract
PURPOSE. Optical coherence tomography (OCT) has enabled ‘‘virtual biopsy’’ of the living human, retina, revolutionizing both basic retina research and clinical practice over the past 25 years. For, most of those years, in parallel, adaptive optics (AO) has been used to improve the transverse, resolution of ophthalmoscopes to foster in vivo study of the retina at the microscopic level. Here,, we review work done over the last 15 years to combine the microscopic transverse resolution of, AO with the microscopic axial resolution of OCT, building AO-OCT systems with the highest, three-dimensional resolution of any existing retinal imaging modality., METHODS. We surveyed the literature to identify the most influential antecedent work,, important milestones in the development of AO-OCT technology, its applications that have, yielded new knowledge, research areas into which it may productively expand, and nascent, applications that have the potential to grow., RESULTS. Initial efforts focused on demonstrating three-dimensional resolution. Since then,, many improvements have been made in resolution and speed, as well as other enhancements, of acquisition and postprocessing techniques. Progress on these fronts has produced, numerous discoveries about the anatomy, function, and optical properties of the retina., CONCLUSIONS. Adaptive optics OCT continues to evolve technically and to contribute to our, basic and clinical knowledge of the retina. Due to its capacity to reveal cellular and, microscopic detail invisible to clinical OCT systems, it is an ideal companion to those, instruments and has the demonstrable potential to produce images that can guide the, interpretation of clinical findings.
| Original language | English (US) |
|---|---|
| Pages (from-to) | OCT51-OCT68 |
| Journal | Investigative Ophthalmology and Visual Science |
| Volume | 57 |
| Issue number | 9 |
| DOIs | |
| State | Published - Jul 1 2016 |
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Keywords
- Adaptive optics
- Optical coherence tomography
- Retinal imaging
ASJC Scopus subject areas
- Ophthalmology
- Sensory Systems
- Cellular and Molecular Neuroscience
Cite this
A review of adaptive optics optical coherence tomography : Technical advances, scientific applications, and the future. / Jonnal, Ravi; Kocaoglu, Omer P.; Zawadzki, Robert; Liu, Zhuolin; Miller, Donald T.; Werner, John S.
In: Investigative Ophthalmology and Visual Science, Vol. 57, No. 9, 01.07.2016, p. OCT51-OCT68.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A review of adaptive optics optical coherence tomography
T2 - Technical advances, scientific applications, and the future
AU - Jonnal, Ravi
AU - Kocaoglu, Omer P.
AU - Zawadzki, Robert
AU - Liu, Zhuolin
AU - Miller, Donald T.
AU - Werner, John S
PY - 2016/7/1
Y1 - 2016/7/1
N2 - PURPOSE. Optical coherence tomography (OCT) has enabled ‘‘virtual biopsy’’ of the living human, retina, revolutionizing both basic retina research and clinical practice over the past 25 years. For, most of those years, in parallel, adaptive optics (AO) has been used to improve the transverse, resolution of ophthalmoscopes to foster in vivo study of the retina at the microscopic level. Here,, we review work done over the last 15 years to combine the microscopic transverse resolution of, AO with the microscopic axial resolution of OCT, building AO-OCT systems with the highest, three-dimensional resolution of any existing retinal imaging modality., METHODS. We surveyed the literature to identify the most influential antecedent work,, important milestones in the development of AO-OCT technology, its applications that have, yielded new knowledge, research areas into which it may productively expand, and nascent, applications that have the potential to grow., RESULTS. Initial efforts focused on demonstrating three-dimensional resolution. Since then,, many improvements have been made in resolution and speed, as well as other enhancements, of acquisition and postprocessing techniques. Progress on these fronts has produced, numerous discoveries about the anatomy, function, and optical properties of the retina., CONCLUSIONS. Adaptive optics OCT continues to evolve technically and to contribute to our, basic and clinical knowledge of the retina. Due to its capacity to reveal cellular and, microscopic detail invisible to clinical OCT systems, it is an ideal companion to those, instruments and has the demonstrable potential to produce images that can guide the, interpretation of clinical findings.
AB - PURPOSE. Optical coherence tomography (OCT) has enabled ‘‘virtual biopsy’’ of the living human, retina, revolutionizing both basic retina research and clinical practice over the past 25 years. For, most of those years, in parallel, adaptive optics (AO) has been used to improve the transverse, resolution of ophthalmoscopes to foster in vivo study of the retina at the microscopic level. Here,, we review work done over the last 15 years to combine the microscopic transverse resolution of, AO with the microscopic axial resolution of OCT, building AO-OCT systems with the highest, three-dimensional resolution of any existing retinal imaging modality., METHODS. We surveyed the literature to identify the most influential antecedent work,, important milestones in the development of AO-OCT technology, its applications that have, yielded new knowledge, research areas into which it may productively expand, and nascent, applications that have the potential to grow., RESULTS. Initial efforts focused on demonstrating three-dimensional resolution. Since then,, many improvements have been made in resolution and speed, as well as other enhancements, of acquisition and postprocessing techniques. Progress on these fronts has produced, numerous discoveries about the anatomy, function, and optical properties of the retina., CONCLUSIONS. Adaptive optics OCT continues to evolve technically and to contribute to our, basic and clinical knowledge of the retina. Due to its capacity to reveal cellular and, microscopic detail invisible to clinical OCT systems, it is an ideal companion to those, instruments and has the demonstrable potential to produce images that can guide the, interpretation of clinical findings.
KW - Adaptive optics
KW - Optical coherence tomography
KW - Retinal imaging
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U2 - 10.1167/iovs.16-19103
DO - 10.1167/iovs.16-19103
M3 - Article
VL - 57
SP - OCT51-OCT68
JO - Investigative Ophthalmology and Visual Science
JF - Investigative Ophthalmology and Visual Science
SN - 0146-0404
IS - 9
ER -