Abstract
Bloodless surgical procedures on the extremities are achieved by application of a pneumatic tourniquet. The ischemia produced has deleterious effects on nerve and muscle function. It has been suggested that temporary interruption of ischemia by a reperfusion interval can prevent muscle and nerve injury. We investigated the muscle and nerve response to 3 hours of tourniquet ischemia, with and without a reperfusion interval after the first 2 hours of application, in a rodent model. Morphometric, contractile, and histologic parameters were measured. Tourniquet ischemia, with and without a reperfusion interval, results in muscle injury and a transient depression of muscle function. Introduction of a reperfusion interval reduces the severity of injury and increases the early rate of recovery. However, the later stages of recovery appear to be unaffected by reperfusion.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1003-1011 |
| Number of pages | 9 |
| Journal | Plastic and Reconstructive Surgery |
| Volume | 94 |
| Issue number | 7 |
| State | Published - 1994 |
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ASJC Scopus subject areas
- Surgery
Cite this
A reperfusion interval reduces the contractile deficit in skeletal muscle following tourniquet ischemia. / Stompro, B. E.; Stevenson, Thomas R; Wineinger, M. A.; Sharman, R. B.; Carlsen, R. C.
In: Plastic and Reconstructive Surgery, Vol. 94, No. 7, 1994, p. 1003-1011.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A reperfusion interval reduces the contractile deficit in skeletal muscle following tourniquet ischemia
AU - Stompro, B. E.
AU - Stevenson, Thomas R
AU - Wineinger, M. A.
AU - Sharman, R. B.
AU - Carlsen, R. C.
PY - 1994
Y1 - 1994
N2 - Bloodless surgical procedures on the extremities are achieved by application of a pneumatic tourniquet. The ischemia produced has deleterious effects on nerve and muscle function. It has been suggested that temporary interruption of ischemia by a reperfusion interval can prevent muscle and nerve injury. We investigated the muscle and nerve response to 3 hours of tourniquet ischemia, with and without a reperfusion interval after the first 2 hours of application, in a rodent model. Morphometric, contractile, and histologic parameters were measured. Tourniquet ischemia, with and without a reperfusion interval, results in muscle injury and a transient depression of muscle function. Introduction of a reperfusion interval reduces the severity of injury and increases the early rate of recovery. However, the later stages of recovery appear to be unaffected by reperfusion.
AB - Bloodless surgical procedures on the extremities are achieved by application of a pneumatic tourniquet. The ischemia produced has deleterious effects on nerve and muscle function. It has been suggested that temporary interruption of ischemia by a reperfusion interval can prevent muscle and nerve injury. We investigated the muscle and nerve response to 3 hours of tourniquet ischemia, with and without a reperfusion interval after the first 2 hours of application, in a rodent model. Morphometric, contractile, and histologic parameters were measured. Tourniquet ischemia, with and without a reperfusion interval, results in muscle injury and a transient depression of muscle function. Introduction of a reperfusion interval reduces the severity of injury and increases the early rate of recovery. However, the later stages of recovery appear to be unaffected by reperfusion.
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M3 - Article
VL - 94
SP - 1003
EP - 1011
JO - Plastic and Reconstructive Surgery
JF - Plastic and Reconstructive Surgery
SN - 0032-1052
IS - 7
ER -