A reperfusion interval reduces the contractile deficit in skeletal muscle following tourniquet ischemia

B. E. Stompro, Thomas R Stevenson, M. A. Wineinger, R. B. Sharman, R. C. Carlsen

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Bloodless surgical procedures on the extremities are achieved by application of a pneumatic tourniquet. The ischemia produced has deleterious effects on nerve and muscle function. It has been suggested that temporary interruption of ischemia by a reperfusion interval can prevent muscle and nerve injury. We investigated the muscle and nerve response to 3 hours of tourniquet ischemia, with and without a reperfusion interval after the first 2 hours of application, in a rodent model. Morphometric, contractile, and histologic parameters were measured. Tourniquet ischemia, with and without a reperfusion interval, results in muscle injury and a transient depression of muscle function. Introduction of a reperfusion interval reduces the severity of injury and increases the early rate of recovery. However, the later stages of recovery appear to be unaffected by reperfusion.

Original languageEnglish (US)
Pages (from-to)1003-1011
Number of pages9
JournalPlastic and Reconstructive Surgery
Volume94
Issue number7
StatePublished - 1994

ASJC Scopus subject areas

  • Surgery

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