A reminder of methylene blue’s effectiveness: In treating vasoplegic syndrome after on-pump cardiac surgery

Joshua Manghelli, Lisa M Brown, Hany B. Tadros, Nabil A. Munfakh

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The inflammatory response induced by cardiopulmonary bypass decreases vascular tone, which in turn can lead to vasoplegic syndrome. Indeed the hypotension consequent to on-pump cardiac surgery often necessitates vasopressor and intravenous fluid support. Methylene blue counteracts vasoplegic syndrome by inhibiting the formation of nitric oxide. We report the use of methylene blue in a 75-year-old man who developed vasoplegic syndrome after cardiac surgery. After the administration of methylene blue, his hypotension improved to the extent that he could be weaned from vasopressors. The use of methylene blue should be considered in patients who develop hypotension refractory to standard treatment after cardiac surgery.

Original languageEnglish (US)
Pages (from-to)491-494
Number of pages4
JournalTexas Heart Institute journal
Volume42
Issue number5
DOIs
StatePublished - Oct 1 2015
Externally publishedYes

Keywords

  • Cardiopulmonary bypass/adverse effects
  • Hemodynamics/drug effects
  • Hypotension/drug therapy
  • Methylene blue/administration and dosage/therapeutic use
  • Nitric oxide/antagonists and inhibitors
  • Shock, vasodilatory/physiopathology
  • Vasoconstrictor agents/therapeutic use
  • Vasodilation/physiology
  • Vasoplegia/etiology/therapy
  • Vasopressors/therapeutic use

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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