Abstract
The aim of this study is to evaluate the treatment outcomes and identify factors associated with adverse tuberculosis treatment outcomes for bacteriologically confirmed pulmonary tuberculosis. Treatment outcomes of pulmonary tuberculosis were evaluated retrospectively among 11,186 smearand/ or culture-positive patients treated between 2006 and 2009 in Istanbul, Turkey. Adverse treatment outcomes were identified in 1,010 (9.0z) patients including death (1.8z), treatment default (6.1z), and treatment failure (1.1z). Factors associated with adverse treatment outcomes included being born abroad (odds ratios [OR], 5.38; 95zconfidence intervals [CI], 3.67-7.91), history of tuberculosis treatment (OR, 3.77; 95z CI, 3.26-4.36), age> 65 years (OR, 2.79; 95z CI, 2.21-3.53), and male gender (OR, 1.91; 95z CI, 1.59-2.27). Death was most strongly associated with age > 65 years (OR, 45.1; 95z CI, 27.0-75.6), followed by treatment default with history of interrupted treatment (OR, 11.6; 95z CI, 8.94-15.1), and treatment failure with prior history of treatment failure (OR, 17.1; 95z CI, 6.97-41.6). Multidrug resistance was strongly associated with adverse treatment outcomes (OR, 10.8; 95zCI, 8.02-14.6). Age > 65 years, male sex, being born abroad, and history of treatment failure were found to be risk factors for adverse treatment outcomes. Hence, patients with any of these characteristics should be carefully monitored and treated aggressively.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 115-120 |
| Number of pages | 6 |
| Journal | Japanese Journal of Infectious Diseases |
| Volume | 66 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2013 |
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ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases
Cite this
A registry-based cohort study of pulmonary tuberculosis treatment outcomes in Istanbul, Turkey. / Babalik, Aylin; Kilicaslan, Zeki; Sevkan Caner, S.; Gungor, Gokay; Gonenc Ortakoylu, M.; Gencer, Serap; Mccurdy, Stephen A.
In: Japanese Journal of Infectious Diseases, Vol. 66, No. 2, 2013, p. 115-120.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A registry-based cohort study of pulmonary tuberculosis treatment outcomes in Istanbul, Turkey
AU - Babalik, Aylin
AU - Kilicaslan, Zeki
AU - Sevkan Caner, S.
AU - Gungor, Gokay
AU - Gonenc Ortakoylu, M.
AU - Gencer, Serap
AU - Mccurdy, Stephen A
PY - 2013
Y1 - 2013
N2 - The aim of this study is to evaluate the treatment outcomes and identify factors associated with adverse tuberculosis treatment outcomes for bacteriologically confirmed pulmonary tuberculosis. Treatment outcomes of pulmonary tuberculosis were evaluated retrospectively among 11,186 smearand/ or culture-positive patients treated between 2006 and 2009 in Istanbul, Turkey. Adverse treatment outcomes were identified in 1,010 (9.0z) patients including death (1.8z), treatment default (6.1z), and treatment failure (1.1z). Factors associated with adverse treatment outcomes included being born abroad (odds ratios [OR], 5.38; 95zconfidence intervals [CI], 3.67-7.91), history of tuberculosis treatment (OR, 3.77; 95z CI, 3.26-4.36), age> 65 years (OR, 2.79; 95z CI, 2.21-3.53), and male gender (OR, 1.91; 95z CI, 1.59-2.27). Death was most strongly associated with age > 65 years (OR, 45.1; 95z CI, 27.0-75.6), followed by treatment default with history of interrupted treatment (OR, 11.6; 95z CI, 8.94-15.1), and treatment failure with prior history of treatment failure (OR, 17.1; 95z CI, 6.97-41.6). Multidrug resistance was strongly associated with adverse treatment outcomes (OR, 10.8; 95zCI, 8.02-14.6). Age > 65 years, male sex, being born abroad, and history of treatment failure were found to be risk factors for adverse treatment outcomes. Hence, patients with any of these characteristics should be carefully monitored and treated aggressively.
AB - The aim of this study is to evaluate the treatment outcomes and identify factors associated with adverse tuberculosis treatment outcomes for bacteriologically confirmed pulmonary tuberculosis. Treatment outcomes of pulmonary tuberculosis were evaluated retrospectively among 11,186 smearand/ or culture-positive patients treated between 2006 and 2009 in Istanbul, Turkey. Adverse treatment outcomes were identified in 1,010 (9.0z) patients including death (1.8z), treatment default (6.1z), and treatment failure (1.1z). Factors associated with adverse treatment outcomes included being born abroad (odds ratios [OR], 5.38; 95zconfidence intervals [CI], 3.67-7.91), history of tuberculosis treatment (OR, 3.77; 95z CI, 3.26-4.36), age> 65 years (OR, 2.79; 95z CI, 2.21-3.53), and male gender (OR, 1.91; 95z CI, 1.59-2.27). Death was most strongly associated with age > 65 years (OR, 45.1; 95z CI, 27.0-75.6), followed by treatment default with history of interrupted treatment (OR, 11.6; 95z CI, 8.94-15.1), and treatment failure with prior history of treatment failure (OR, 17.1; 95z CI, 6.97-41.6). Multidrug resistance was strongly associated with adverse treatment outcomes (OR, 10.8; 95zCI, 8.02-14.6). Age > 65 years, male sex, being born abroad, and history of treatment failure were found to be risk factors for adverse treatment outcomes. Hence, patients with any of these characteristics should be carefully monitored and treated aggressively.
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UR - http://www.scopus.com/inward/citedby.url?scp=84875315581&partnerID=8YFLogxK
U2 - 10.7883/yoken.66.115
DO - 10.7883/yoken.66.115
M3 - Article
C2 - 23514907
AN - SCOPUS:84875315581
VL - 66
SP - 115
EP - 120
JO - Japanese Journal of Infectious Diseases
JF - Japanese Journal of Infectious Diseases
SN - 1344-6304
IS - 2
ER -