A reference database of cartilage 3T MRI T2 values in knees without diagnostic evidence of cartilage degeneration

Data from the osteoarthritis initiative

G. B. Joseph, C. E. McCulloch, M. C. Nevitt, U. Heilmeier, Lorenzo Nardo, J. A. Lynch, F. Liu, T. Baum, T. M. Link

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objective: 1) To establish a gender- and BMI-specific reference database of cartilage T2 values, and 2) to assess the associations between cartilage T2 values and gender, age, and BMI in knees without radiographic osteoarthritis or MRI-based (WORMS 0/1) evidence of cartilage degeneration. Design: 481 subjects aged 45-65 years with Kellgren-Lawrence Scores 0/1 in the study knee were selected. Baseline morphologic cartilage 3T MRI readings (WORMS scoring) and T2 measurements (resolution=0.313mm×0.446mm) were performed in the medial and lateral femurs, medial and lateral tibias, and patella compartments. To create a reference database, a logarithmic transformation was applied to the data to obtain the 5th-95th percentile values for T2. Results: Significant differences in mean cartilage T2 values were observed between joint compartments. Although females had slightly higher T2 values than males in a majority of compartments, the differences were only significant in the medial femur (P<0.0001). A weak positive association was seen between age and T2 in all compartments, most pronounced in the patella (3.27% increase in median T2/10 years, P=0.009). Significant associations between BMI and T2 were observed, most pronounced in the lateral tibia (5.33% increase in median T2/5kg/m2 increase in BMI, P<0.0001), and medial tibia (4.81% increase in median T2 /5kg/m2 increase in BMI, P<0.0001). Conclusions: This study established the first reference database of T2 values in a large sample of morphologically normal cartilage plates in knees without radiographic knee osteoarthritis (OA). While cartilage T2 values were weakly associated with age and gender, they had the highest correlations with BMI.

Original languageEnglish (US)
Pages (from-to)897-905
Number of pages9
JournalOsteoarthritis and Cartilage
Volume23
Issue number6
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Fingerprint

Cartilage
Osteoarthritis
Magnetic resonance imaging
Knee
Databases
Tibia
Patella
Femur
Knee Osteoarthritis
Reading
Joints

Keywords

  • Cartilage
  • Magnetic resonance imaging
  • Osteoarthritis
  • Osteoarthritis initiative
  • T2 mapping

ASJC Scopus subject areas

  • Rheumatology
  • Orthopedics and Sports Medicine
  • Biomedical Engineering

Cite this

A reference database of cartilage 3T MRI T2 values in knees without diagnostic evidence of cartilage degeneration : Data from the osteoarthritis initiative. / Joseph, G. B.; McCulloch, C. E.; Nevitt, M. C.; Heilmeier, U.; Nardo, Lorenzo; Lynch, J. A.; Liu, F.; Baum, T.; Link, T. M.

In: Osteoarthritis and Cartilage, Vol. 23, No. 6, 01.01.2015, p. 897-905.

Research output: Contribution to journalArticle

Joseph, G. B. ; McCulloch, C. E. ; Nevitt, M. C. ; Heilmeier, U. ; Nardo, Lorenzo ; Lynch, J. A. ; Liu, F. ; Baum, T. ; Link, T. M. / A reference database of cartilage 3T MRI T2 values in knees without diagnostic evidence of cartilage degeneration : Data from the osteoarthritis initiative. In: Osteoarthritis and Cartilage. 2015 ; Vol. 23, No. 6. pp. 897-905.
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abstract = "Objective: 1) To establish a gender- and BMI-specific reference database of cartilage T2 values, and 2) to assess the associations between cartilage T2 values and gender, age, and BMI in knees without radiographic osteoarthritis or MRI-based (WORMS 0/1) evidence of cartilage degeneration. Design: 481 subjects aged 45-65 years with Kellgren-Lawrence Scores 0/1 in the study knee were selected. Baseline morphologic cartilage 3T MRI readings (WORMS scoring) and T2 measurements (resolution=0.313mm×0.446mm) were performed in the medial and lateral femurs, medial and lateral tibias, and patella compartments. To create a reference database, a logarithmic transformation was applied to the data to obtain the 5th-95th percentile values for T2. Results: Significant differences in mean cartilage T2 values were observed between joint compartments. Although females had slightly higher T2 values than males in a majority of compartments, the differences were only significant in the medial femur (P<0.0001). A weak positive association was seen between age and T2 in all compartments, most pronounced in the patella (3.27{\%} increase in median T2/10 years, P=0.009). Significant associations between BMI and T2 were observed, most pronounced in the lateral tibia (5.33{\%} increase in median T2/5kg/m2 increase in BMI, P<0.0001), and medial tibia (4.81{\%} increase in median T2 /5kg/m2 increase in BMI, P<0.0001). Conclusions: This study established the first reference database of T2 values in a large sample of morphologically normal cartilage plates in knees without radiographic knee osteoarthritis (OA). While cartilage T2 values were weakly associated with age and gender, they had the highest correlations with BMI.",
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T2 - Data from the osteoarthritis initiative

AU - Joseph, G. B.

AU - McCulloch, C. E.

AU - Nevitt, M. C.

AU - Heilmeier, U.

AU - Nardo, Lorenzo

AU - Lynch, J. A.

AU - Liu, F.

AU - Baum, T.

AU - Link, T. M.

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N2 - Objective: 1) To establish a gender- and BMI-specific reference database of cartilage T2 values, and 2) to assess the associations between cartilage T2 values and gender, age, and BMI in knees without radiographic osteoarthritis or MRI-based (WORMS 0/1) evidence of cartilage degeneration. Design: 481 subjects aged 45-65 years with Kellgren-Lawrence Scores 0/1 in the study knee were selected. Baseline morphologic cartilage 3T MRI readings (WORMS scoring) and T2 measurements (resolution=0.313mm×0.446mm) were performed in the medial and lateral femurs, medial and lateral tibias, and patella compartments. To create a reference database, a logarithmic transformation was applied to the data to obtain the 5th-95th percentile values for T2. Results: Significant differences in mean cartilage T2 values were observed between joint compartments. Although females had slightly higher T2 values than males in a majority of compartments, the differences were only significant in the medial femur (P<0.0001). A weak positive association was seen between age and T2 in all compartments, most pronounced in the patella (3.27% increase in median T2/10 years, P=0.009). Significant associations between BMI and T2 were observed, most pronounced in the lateral tibia (5.33% increase in median T2/5kg/m2 increase in BMI, P<0.0001), and medial tibia (4.81% increase in median T2 /5kg/m2 increase in BMI, P<0.0001). Conclusions: This study established the first reference database of T2 values in a large sample of morphologically normal cartilage plates in knees without radiographic knee osteoarthritis (OA). While cartilage T2 values were weakly associated with age and gender, they had the highest correlations with BMI.

AB - Objective: 1) To establish a gender- and BMI-specific reference database of cartilage T2 values, and 2) to assess the associations between cartilage T2 values and gender, age, and BMI in knees without radiographic osteoarthritis or MRI-based (WORMS 0/1) evidence of cartilage degeneration. Design: 481 subjects aged 45-65 years with Kellgren-Lawrence Scores 0/1 in the study knee were selected. Baseline morphologic cartilage 3T MRI readings (WORMS scoring) and T2 measurements (resolution=0.313mm×0.446mm) were performed in the medial and lateral femurs, medial and lateral tibias, and patella compartments. To create a reference database, a logarithmic transformation was applied to the data to obtain the 5th-95th percentile values for T2. Results: Significant differences in mean cartilage T2 values were observed between joint compartments. Although females had slightly higher T2 values than males in a majority of compartments, the differences were only significant in the medial femur (P<0.0001). A weak positive association was seen between age and T2 in all compartments, most pronounced in the patella (3.27% increase in median T2/10 years, P=0.009). Significant associations between BMI and T2 were observed, most pronounced in the lateral tibia (5.33% increase in median T2/5kg/m2 increase in BMI, P<0.0001), and medial tibia (4.81% increase in median T2 /5kg/m2 increase in BMI, P<0.0001). Conclusions: This study established the first reference database of T2 values in a large sample of morphologically normal cartilage plates in knees without radiographic knee osteoarthritis (OA). While cartilage T2 values were weakly associated with age and gender, they had the highest correlations with BMI.

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