A re-evaluation of the role of B cells in protective immunity to Chlamydia infection

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Chlamydia trachomatis is the etiological agent of the most commonly reported bacterial sexual transmitted infection (STI) in North America and Europe. The control of Chlamydia infection is hindered by the asymptomatic nature of initial infection but the consequence of untreated infection seriously threatens the reproductive health of young women. Unfortunately, there is no licensed vaccine for Chlamydia vaccine, in part due to our incomplete understanding of the immune response to Chlamydia urogenital infection. It has been well established that T cell-mediated immunity plays a dominant role in protective immunity against Chlamydia and thus the importance of B cells is somewhat underappreciated. Here, we summarize recent progress on understanding the role of B cells during Chlamydia genital tract infections and discuss how B cells and humoral immunity make an effective contribution to host defense against important intracellular pathogens, including Chlamydia.

Original languageEnglish (US)
Pages (from-to)88-93
Number of pages6
JournalImmunology Letters
Volume164
Issue number2
DOIs
StatePublished - Apr 1 2015

Fingerprint

Chlamydia Infections
Chlamydia
Immunity
B-Lymphocytes
Vaccines
Infection
Reproductive Tract Infections
Chlamydia trachomatis
Reproductive Health
Humoral Immunity
North America
Cellular Immunity
T-Lymphocytes

Keywords

  • Antibody
  • B cells
  • Chlamydia
  • Intracellular infections

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

A re-evaluation of the role of B cells in protective immunity to Chlamydia infection. / Li, Lin Xi; Mcsorley, Stephen J.

In: Immunology Letters, Vol. 164, No. 2, 01.04.2015, p. 88-93.

Research output: Contribution to journalArticle

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