A re-evaluation of the role of B cells in protective immunity to Chlamydia infection

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Chlamydia trachomatis is the etiological agent of the most commonly reported bacterial sexual transmitted infection (STI) in North America and Europe. The control of Chlamydia infection is hindered by the asymptomatic nature of initial infection but the consequence of untreated infection seriously threatens the reproductive health of young women. Unfortunately, there is no licensed vaccine for Chlamydia vaccine, in part due to our incomplete understanding of the immune response to Chlamydia urogenital infection. It has been well established that T cell-mediated immunity plays a dominant role in protective immunity against Chlamydia and thus the importance of B cells is somewhat underappreciated. Here, we summarize recent progress on understanding the role of B cells during Chlamydia genital tract infections and discuss how B cells and humoral immunity make an effective contribution to host defense against important intracellular pathogens, including Chlamydia.

Original languageEnglish (US)
Pages (from-to)88-93
Number of pages6
JournalImmunology Letters
Volume164
Issue number2
DOIs
StatePublished - Apr 1 2015

Keywords

  • Antibody
  • B cells
  • Chlamydia
  • Intracellular infections

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Fingerprint Dive into the research topics of 'A re-evaluation of the role of B cells in protective immunity to Chlamydia infection'. Together they form a unique fingerprint.

  • Cite this