A rare lethal combination of premature closure of the foramen ovale and d-transposition of the great arteries with intact ventricular septum

Hui Li Chiou, Anita Moon-Grady, Rafael Rodriguez, Thomas Konia, Mark D Parrish, Jay M Milstein

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We report an infant who presented with cyanosis after birth and was unresponsive to all resuscitative efforts. Emergent echocardiogram showed d-transposition of the great arteries (d-TGA) with an intact ventricular septum. Attempts to perform a bedside balloon atrial septostomy failed due to inability to traverse the atrial septum. Autopsy revealed d-TGA with intact atrial and ventricular septa and patent ductus arteriosus. Though no survivors have been reported for this rare lethal combination of lesions thus far in the literature, we speculate that recent advances in fetal treatment may soon be applicable to infants with this condition.

Original languageEnglish (US)
JournalInternational Journal of Cardiology
Volume130
Issue number2
DOIs
StatePublished - Nov 12 2008

Fingerprint

Foramen Ovale
Atrial Septum
Ventricular Septum
Transposition of Great Vessels
Cyanosis
Patent Ductus Arteriosus
Survivors
Autopsy
Parturition
Therapeutics

Keywords

  • Congenital heart defects
  • D-transposition of the great arteries
  • Premature closure of the foramen ovale

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

@article{3ee1282dcafa435a8a7c78c741ff2ebf,
title = "A rare lethal combination of premature closure of the foramen ovale and d-transposition of the great arteries with intact ventricular septum",
abstract = "We report an infant who presented with cyanosis after birth and was unresponsive to all resuscitative efforts. Emergent echocardiogram showed d-transposition of the great arteries (d-TGA) with an intact ventricular septum. Attempts to perform a bedside balloon atrial septostomy failed due to inability to traverse the atrial septum. Autopsy revealed d-TGA with intact atrial and ventricular septa and patent ductus arteriosus. Though no survivors have been reported for this rare lethal combination of lesions thus far in the literature, we speculate that recent advances in fetal treatment may soon be applicable to infants with this condition.",
keywords = "Congenital heart defects, D-transposition of the great arteries, Premature closure of the foramen ovale",
author = "Chiou, {Hui Li} and Anita Moon-Grady and Rafael Rodriguez and Thomas Konia and Parrish, {Mark D} and Milstein, {Jay M}",
year = "2008",
month = "11",
day = "12",
doi = "10.1016/j.ijcard.2007.11.055",
language = "English (US)",
volume = "130",
journal = "International Journal of Cardiology",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - A rare lethal combination of premature closure of the foramen ovale and d-transposition of the great arteries with intact ventricular septum

AU - Chiou, Hui Li

AU - Moon-Grady, Anita

AU - Rodriguez, Rafael

AU - Konia, Thomas

AU - Parrish, Mark D

AU - Milstein, Jay M

PY - 2008/11/12

Y1 - 2008/11/12

N2 - We report an infant who presented with cyanosis after birth and was unresponsive to all resuscitative efforts. Emergent echocardiogram showed d-transposition of the great arteries (d-TGA) with an intact ventricular septum. Attempts to perform a bedside balloon atrial septostomy failed due to inability to traverse the atrial septum. Autopsy revealed d-TGA with intact atrial and ventricular septa and patent ductus arteriosus. Though no survivors have been reported for this rare lethal combination of lesions thus far in the literature, we speculate that recent advances in fetal treatment may soon be applicable to infants with this condition.

AB - We report an infant who presented with cyanosis after birth and was unresponsive to all resuscitative efforts. Emergent echocardiogram showed d-transposition of the great arteries (d-TGA) with an intact ventricular septum. Attempts to perform a bedside balloon atrial septostomy failed due to inability to traverse the atrial septum. Autopsy revealed d-TGA with intact atrial and ventricular septa and patent ductus arteriosus. Though no survivors have been reported for this rare lethal combination of lesions thus far in the literature, we speculate that recent advances in fetal treatment may soon be applicable to infants with this condition.

KW - Congenital heart defects

KW - D-transposition of the great arteries

KW - Premature closure of the foramen ovale

UR - http://www.scopus.com/inward/record.url?scp=54549091113&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=54549091113&partnerID=8YFLogxK

U2 - 10.1016/j.ijcard.2007.11.055

DO - 10.1016/j.ijcard.2007.11.055

M3 - Article

VL - 130

JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

IS - 2

ER -